Risk Factors for Helminth, Malaria, and HIV Infection in Pregnancy in Entebbe, Uganda
Risk Factors for Helminth, Malaria, and HIV Infection in Pregnancy in Entebbe, Uganda
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乌干达恩德培妊娠期蠕虫、疟疾和艾滋病毒感染的危险因素
DOI：
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发表时间：
2009
影响因子：
3.8
通讯作者：
A. Elliott
中科院分区：
文献类型：
--
作者：
Patrick W Woodburn;L. Muhangi;S. Hillier;Juliet Ndibazza;P. Namujju;Moses Kizza;Christine Ameke;N. Omoding;M. Booth;A. Elliott
妊娠期感染可能对母亲和婴儿造成严重后果。对感染风险因素的评估有助于规划干预措施和分析感染对健康结果的影响。目的描述乌干达孕妇在妊娠期驱虫试验干预前感染蠕虫、疟疾和艾滋病毒的危险因素。方法2003年4月至2005年11月，对2,507名孕妇进行了研究。对参与者进行了访谈，并采集了血液和粪便样本;绘制了登记时的居住地点。人口统计学，社会经济，行为和其他危险因素进行建模，使用逻辑回归。结果寄生虫、疟疾和HIV感染率较高。所有蠕虫和疟疾寄生虫血症在年轻女性中更常见，教育对每一种感染都有保护作用。出生地和/或部落影响所有蠕虫的蠕虫感染的地理分布在乌干达的模式一致。四种不同的地源蠕虫（钩虫、鞭虫、蛔虫和毛圆线虫）在登记期间的流行率呈下降趋势。钩虫和艾滋病毒之间呈负相关，钩虫和艾滋病毒阳性妇女中CD 4计数低之间呈负相关。在当地，血吸虫病和艾滋病毒的高流行率发生在湖滨社区。结论蠕虫、疟疾和艾滋病毒的干预措施需要针对学校内外的年轻妇女。必须继续促进疟疾和艾滋病毒感染的产前干预措施。来自蠕虫感染高风险地区的妇女在迁移到低风险地区后仍处于高风险状态，反之亦然，但总体而言，地球蠕虫似乎在这一人群中越来越不常见。高危人群，如渔业社区，需要针对血吸虫病和艾滋病毒感染作出直接努力。
Background Infections during pregnancy may have serious consequences for both mother and baby. Assessment of risk factors for infections informs planning of interventions and analysis of the impact of infections on health outcomes. Objectives To describe risk factors for helminths, malaria and HIV in pregnant Ugandan women before intervention in a trial of de-worming in pregnancy. Methods The trial recruited 2,507 pregnant women between April 2003 and November 2005. Participants were interviewed and blood and stool samples obtained; location of residence at enrolment was mapped. Demographic, socioeconomic, behavioral and other risk factors were modelled using logistic regression. Results There was a high prevalence of helminth, malaria and HIV infection, as previously reported. All helminths and malaria parasitemia were more common in younger women, and education was protective against every infection. Place of birth and/or tribe affected all helminths in a pattern consistent with the geographical distribution of helminth infections in Uganda. Four different geohelminths (hookworm, Trichuris, Ascaris and Trichostrongylus) showed a downwards trend in prevalence during the enrolment period. There was a negative association between hookworm and HIV, and between hookworm and low CD4 count among HIV-positive women. Locally, high prevalence of schistosomiasis and HIV occurred in lakeshore communities. Conclusions Interventions for helminths, malaria and HIV need to target young women both in and out of school. Antenatal interventions for malaria and HIV infection must continue to be promoted. Women originating from a high risk area for a helminth infection remain at high risk after migration to a lower-risk area, and vice versa, but overall, geohelminths seem to be becoming less common in this population. High risk populations, such as fishing communities, require directed effort against schistosomiasis and HIV infection.
DOI：
10.1016/b978-0-7020-7959-7.00057-9
发表时间：
2024
期刊：
--
影响因子：
--
作者：
Bustinduy A
通讯作者：
Bustinduy A