Persistence of High Neutralizing Antibody Titers after Neonatal and Early Infantile Infection with Parechovirus-A3.

Persistence of High Neutralizing Antibody Titers after Neonatal and Early Infantile Infection with Parechovirus-A3.
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新生儿和早期婴儿感染副肠病毒 A3 后高中和抗体滴度的持续性。

DOI:
10.1097/inf.0000000000002245
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发表时间:
2018
期刊:
Pediatr Infect Dis J.
影响因子:
--
通讯作者:
Saitoh A.
Saitoh A.
中科院分区:
--
文献类型:
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作者:
Izumita R;Aizawa Y;Watanabe K;Saitoh A.

文献摘要

相似文献

这项为期3年的随访研究评价了发生PeV-A3感染的新生儿和幼儿中抗PeV-A3的中和抗体滴度(NAT)。所有儿童在疾病发作时NAT较低,在婴儿期感染后NAT较高。在3岁时,所有16例受试患者均具有抗PeV-A3的高NAT(≥ 1:512),表明特异性PeV-A3 NAT持续至儿童期。
This 3-year follow-up study evaluated neutralizing antibody titers (NATs) against parechovirus-A3 (PeV-A3) in neonates and young infants who developed PeV-A3 infection. All children had low NATs at disease onset and high NATs after infection during infancy. At age 3 years, all 16 patients tested had high NATs (≥ 1: 512) against PeV-A3 indicating that specific PeV-A3 NATs persist into childhood.