Child symptoms, parent behaviors, and family strain in long-term survivors of childhood acute lymphoblastic leukemia.
Child symptoms, parent behaviors, and family strain in long-term survivors of childhood acute lymphoblastic leukemia.
复制标题
DOI：
10.1002/pon.4769
复制
发表时间：
2018-08
期刊：
影响因子：
3.6
通讯作者：
Krull KR
中科院分区：
文献类型：
--
作者：
Huang IC;Brinkman TM;Mullins L;Pui CH;Robison LL;Hudson MM;Krull KR
家庭环境和父母因素如何影响儿童癌症幸存者的健康状况和症状尚未得到充分研究。我们研究了家庭凝聚力、父母痛苦和过度保护对儿童急性淋巴细胞白血病（ALL）幸存者儿童症状负担、健康相关生活质量（HRQOL）和家庭紧张的影响。213名接受化疗的儿童的父母只有在幸存者确诊后至少5年才完成一项调查。采用家庭环境量表、简要症状量表-18、父母保护量表、PedsQL和对家庭的影响量表分别评估家庭凝聚力、父母困扰、过度保护、儿童症状负担和HRQOL、家庭紧张。通过通径分析量化家庭凝聚力对家庭压力的影响，包括父母痛苦、过度保护、儿童症状和HRQOL。较低的家庭凝聚力（β=0.06, 95% CI=0.01 ~ 0.13）、较高的父母痛苦（β=0.35, 95% CI=0.20 ~ 0.45）和过度保护（β=0.17, 95% CI=0.01 ~ 0.32）与儿童症状负担加重相关。症状负担加重与较差的儿童HRQOL相关（β=0.66, 95% CI=0.57 ~ 0.75），而较差的儿童HRQOL与较多的家庭菌株相关（β=0.11, 95% CI=0.01 ~ 0.22）。较低的母亲受教育程度与过度保护（β= - 0.23, 95% CI= - 0.33至- 0.12）、更多的儿童症状（β= - 0.30, 95% CI= - 0.41至- 0.16）、较差的儿童HRQOL （β= - 0.36, 95% CI= - 0.46至- 0.21）和更多的家庭菌株（β= - 0.15, 95% CI= - 0.23至- 0.08）相关。家庭和父母因素对儿童期ALL幸存者的健康结果有影响。加强家庭凝聚力、减少父母的痛苦和过度保护以及改善儿童症状的干预措施可能会改善家庭功能。
How family environment and parental factors affect health status and symptoms in childhood cancer survivors is understudied. We examined the influence of family cohesion, parent distress, and overprotection on child symptom burden and health-related quality of life (HRQOL) and family strain in survivors of childhood acute lymphoblastic leukemia (ALL). Parents of 213 children treated with chemotherapy-only completed a survey when survivors were at least five-years post-diagnosis. Family Environment Scale, Brief Symptom Inventory-18, Parent Protection Scale, PedsQL, and Impact on Family were used to assess family cohesion, parental distress, overprotection, child symptom burden and HRQOL, and family strain, respectively. Path analysis was conducted to quantify effects of family cohesion on family strain through parental distress, overprotection, child symptoms, and HRQOL. Lower family cohesion (β=0.06, 95% CI=0.01 to 0.13), higher parental distress (β=0.35, 95% CI=0.20 to 0.45), and overprotection (β=0.17, 95% CI=0.01 to 0.32) were associated with more child symptom burden. More symptom burden were associated with poorer child HRQOL (β=0.66, 95% CI=0.57 to 0.75), which in turn was associated with more family strain (β=0.11, 95% CI=0.01 to 0.22). Lower maternal education was associated with overprotection (β=−0.23, 95% CI=−0.33 to −0.12), more child symptoms (β=−0.30, 95% CI=−0.41 to −0.16), poorer child HRQOL (β=−0.36, 95% CI=−0.46 to −0.21), and more family strain (β=−0.15, 95% CI=−0.23 to −0.08). Family and parental factors contributed to health outcomes of childhood ALL survivors. Interventions to enhance family cohesion, decrease parental distress and overprotection, and ameliorate child symptoms may improve family functioning.
登录
查看更多内容
影响因子：
0.9
作者：
Manne, S;Miller, D;Redd, WH
通讯作者：
Redd, WH
影响因子：
0.9
作者：
Morris, JAB;Blount, RL;Brown, RT
通讯作者：
Brown, RT
影响因子：
3.6
作者：
Phipps, S;Dunavant, M;Rai, SN
通讯作者：
Rai, SN
影响因子：
2.7
作者：
Alderfer, Melissa A.;Navsaria, Neha;Kazak, Anne E.
通讯作者：
Kazak, Anne E.
影响因子：
3.6
作者：
Robinson, Kristen E.;Gerhardt, Cynthia A.;Noll, Robert B.
通讯作者：
Noll, Robert B.