QUANTITATION OF BLOOD-BRAIN-BARRIER DEFECT BY MAGNETIC-RESONANCE-IMAGING AND GADOLINIUM-DTPA IN PATIENTS WITH MULTIPLE-SCLEROSIS AND BRAIN-TUMORS
QUANTITATION OF BLOOD-BRAIN-BARRIER DEFECT BY MAGNETIC-RESONANCE-IMAGING AND GADOLINIUM-DTPA IN PATIENTS WITH MULTIPLE-SCLEROSIS AND BRAIN-TUMORS
复制标题
DOI：
10.1002/mrm.1910160111
复制
发表时间：
1990-10-01
影响因子：
3.3
通讯作者：
PAULSON, OB
中科院分区：
文献类型：
--
作者：
LARSSON, HBW;STUBGAARD, M;PAULSON, OB
在这项研究中，通过使用MRI对多发性硬化症或脑肿瘤患者的血脑屏障（BBB）缺陷程度进行定量显示是可能的。作为BBB对钆-DTPA（Gd-DTPA）的渗透性的量度，使用每单位脑质量的每单位分布体积的通量。通过引入纵向弛豫速率（R1）作为在BBB上跨毛细血管运输的数学模型中脑组织中Gd-DTPA浓度的量度，发现了该量。观察到的数据点和模型之间的高度一致性被发现，结果是可比的，从类似的研究中使用正电子发射断层扫描得到的结果。通过MRI定量BBB缺陷的可能性的提高可能提供关于发病机制或病因学的新信息，并导致颅内疾病治疗效果的监测方法的改进。
In this study quantitation of the degree of deficiency of the blood-brain barrier (BBB) in patients with multiple sclerosis or brain tumors, by using MRI, is shown to be possible. As a measure of permeability of the BBB to Gadolinium-DTPA (Gd-DTPA) the flux per unit of distribution volume per unit of brain mass was used. This quantity was found by introducing the longitudinal relaxation rate (R1) as a measure of concentration of Gd-DTPA in the brain tissue in the mathematical model for the transcapillary transport over the BBB. High accordance between the observed data points and the model was found, and the results were comparable to results obtained from similar studies using positron emission tomography. The improved possibility of quantitating the defect of the BBB by MRI may give new information about pathogenesis or etiology, and leads to improved methods in monitoring the efficacy of treatments in intracranial diseases.