Incidence and signficiance of mixed affective states in a bipolar population.
Incidence and signficiance of mixed affective states in a bipolar population.
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双相人群中混合情感状态的发生率和重要性。
DOI：
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发表时间：
1976
影响因子：
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通讯作者：
D. Kupfer
中科院分区：
文献类型：
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作者：
J. Himmelhoch;D. Mulla;J. Neil;T. Detre;D. Kupfer
克雷佩林首先描述了躁狂抑郁症患者同时存在躁狂和抑郁症状。这种所谓的混合状态在最近关于双相情感障碍性质的假设中具有重要的理论意义。在这项调查中，混合状态被证明是在84躁狂抑郁症门诊患者的31%的初始发作。此外，“混合”特征的存在与疾病的严重程度或情绪循环无关，但与镇静剂滥用和对精神药理学治疗反应不良相关。这些结果表明，“连续统假说”及其卫星理论代表了可行的概念化的性质躁狂抑郁症。
The simultaneous existence of manic and depressive symptoms in a manic-depressive patient was first described by Kraepelin. This so-called mixed state has come to have much theoretical significance in recent hypotheses about the nature of bipolar affective disorders. In this investigation a mixed state is shown to be the initial episode in 31% of 84 manic-depressive outpatients. Moreover, the presence of "mixed" features does not correlate with severity of illness or mood circularity, but does correlate with sedative abuse and poor response to psychopharmacologic treatment. These results suggest that the "continuum hypothesis" and its satellite theories represent viable conceptualizations of the nature of manic-depressive illness.