The biomarkers related to immune related adverse events caused by immune checkpoint inhibitors.
The biomarkers related to immune related adverse events caused by immune checkpoint inhibitors.
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DOI：
10.1186/s13046-020-01749-x
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发表时间：
2020-12-14
期刊：
影响因子：
--
通讯作者：
Guo H
中科院分区：
文献类型：
--
作者：
Jia XH;Geng LY;Jiang PP;Xu H;Nan KJ;Yao Y;Jiang LL;Sun H;Qin TJ;Guo H
免疫检查点抑制物(ICIS)是一种不同于传统治疗的有效肿瘤治疗模式，其抗肿瘤效果前所未有，但免疫相关不良事件(IrAEs)的出现阻碍了ICI治疗的前景。IrAEs是一种由免疫系统的非特异性激活引起的离散毒性，几乎可以影响所有组织和器官。目前，对生物标志物的研究主要集中在胃肠道、内分泌系统、皮肤和肺。一些可能的假说集中在免疫系统的过度激活、炎性细胞因子的过度释放、先前存在的自身抗体水平的升高以及肿瘤和正常组织之间存在共同的抗原。这篇综述列出了目前可能预测irAEs的生物标记物，以及它们对非特异性和器官特异性生物标记物的可能机制。然而，对irAEs的预测仍然是筛选和识别易患irAEs并可能受益于ICIS的患者的主要临床挑战。补充信息见10.1186/s13046-020-01749-x。
The enthusiasm for immune checkpoint inhibitors (ICIs), an efficient tumor treatment model different from traditional treatment, is based on their unprecedented antitumor effect, but the occurrence of immune-related adverse events (irAEs) is an obstacle to the prospect of ICI treatment. IrAEs are a discrete toxicity caused by the nonspecific activation of the immune system and can affect almost all tissues and organs. Currently, research on biomarkers mainly focuses on the gastrointestinal tract, endocrine system, skin and lung. Several potential hypotheses concentrate on the overactivation of the immune system, excessive release of inflammatory cytokines, elevated levels of pre-existing autoantibodies, and presence of common antigens between tumors and normal tissues. This review lists the current biomarkers that might predict irAEs and their possible mechanisms for both nonspecific and organ-specific biomarkers. However, the prediction of irAEs remains a major clinical challenge to screen and identify patients who are susceptible to irAEs and likely to benefit from ICIs. Supplementary information accompanies this paper at 10.1186/s13046-020-01749-x.
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影响因子：
8.4
作者：
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DOI：
10.1210/jc.2016-2300
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期刊：
The Journal of clinical endocrinology and metabolism
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