Dietary docosahexaenoic acid affects stearic acid desaturation in spontaneously hypertensive rats
Dietary docosahexaenoic acid affects stearic acid desaturation in spontaneously hypertensive rats
复制标题
DOI：
10.1007/s11745-000-0612-0
复制
发表时间：
2000-09-01
期刊：
影响因子：
1.9
通讯作者：
Poisson, JPG
中科院分区：
文献类型：
--
作者：
Engler, MM;Bellenger-Germain, SH;Poisson, JPG
二十二碳六烯酸（DHA，22：6 n-3）是一种n-3多不饱和脂肪酸，可减轻自发性高血压大鼠（SHR）的高血压发展。研究了DHA对年轻SHR肝微粒体δ-9-去饱和酶活性和脂肪酸组成的影响。两组SHR分别饲喂富含DHA的饲料和对照饲料6周。在饮食处理后测定肝微粒体中的去饱和酶活性和脂肪酸组成。在DHA喂养的SHR中，δ-9-去饱和酶活性降低了53%，并伴随着肝微粒体中16：0含量的增加和16：1 n-7含量的减少。DHA饮食还增加了二十碳五烯酸（20：5 n-3）和DHA的水平。n-6脂肪酸含量也受到影响，在DHA喂养的SHR中，γ-亚麻酸（18：3 n-6），花生四烯酸（20：4 n-6），肾上腺酸（22：4 n-6）和二十二碳五烯酸（22：5 n-6）减少。较高比例的二高-γ-亚麻酸（20：3 n-6）和较低比例的20：4 n-6指示受损的δ-5-去饱和酶活性。脂肪酸组成和代谢的改变可能有助于BHA以前报道的降压作用。
Docosahexaenoic acid (DHA, 22:6n-3) is an n-3 polyunsaturated fatty acid which attenuates the development of hypertension in spontaneously hypertensive rats (SHR). The effects of DHA on delta-9-desaturase activity in hepatic microsomes and fatty acid composition were examined in young SHR. Two groups of SHR were fed either a DHA-enriched diet or a control diet for 6 wk. Desaturase activity and fatty acid composition were determined in hepatic microsomes following the dietary treatments. Delta-9-desaturase activity was decreased by 53% in DHA-fed SHR and was accompanied by an increase in 16:0 and a reduction in 16:1n-7 content in hepatic microsomes. The DHA diet also increased the levels of eicosapentaenoic acid (20:5n-3) and DHA. The n-6 fatty acid content was also affected in DHA-fed SHR as reflected by a decrease in gamma-linolenic acid (18:3n-6), arachidonic acid (20:4n-6), adrenic acid (22:4n-6), and docosapentaenoic acid (22:5n-6). A higher proportion of dihomo-gamma-linolenic acid (20:3n-6) and a lower proportion of 20:4n-6 is indicative of impaired delta-5-desaturase activity. The alterations in fatty acid composition and metabolism may contribute to the antihypertensive effect of BHA previously reported.