Assessment of the factors associated with flavivirus seroprevalence in a population in Southern Vietnam
Assessment of the factors associated with flavivirus seroprevalence in a population in Southern Vietnam
复制标题
DOI：
10.1017/s0950268801006495
复制
发表时间：
2002-04-01
影响因子：
4.2
通讯作者：
Farrar, J
中科院分区：
文献类型：
--
作者：
Bartley, LM;Carabin, H;Farrar, J
登革热和日本脑炎黄病毒导致严重疾病，并在越南南部高度流行。这项研究评估了社会人口学因素与该地区黄病毒血清阳性率之间的关系。从1996年4月至1997年8月收集了308名社区和医院调查对象的血清，并用间接酶联免疫吸附试验进行了检测。用多变量Logistic回归分析与血清阳性率相关的因素。在这份关于越南黄病毒感染的调整流行优势比(POR)的第一份报告中，血清阳性与儿童年龄的增加(儿童与成人的多重回归系数=-4.975，儿童的年龄=0.354)以及与周围农村地区相比在城市居住有关。与年龄的关联表明，受试者最有可能在儿童早期感染。这是设计越南健康教育和免疫方案的关键。
Dengue and Japanese encephalitis flaviviruses cause severe disease and are hyperendemic in southern Vietnam. This study assesses associations between sociodemographic factors and flavivirus seroprevalence in this region. Sera were collected from 308 community and hospital-based subjects between April 1996 and August 1997 and tested with an indirect ELISA. The factors associated with seroprevalence were assessed using multivariate logistic regression. In this first report of adjusted prevalence odds ratios (POR) for flavivirus infection in Vietnam, seropositivity was associated with increasing age in children (multiple regression coefficients for a child compared to an adult = -4.975 and for age in children = 0.354) and residence in the city compared to surrounding rural districts. The association with age indicates that subjects were most likely to have acquired infection in early childhood. This is key to the design of Vietnamese health education and immunization programmes.