Graphene-kaolin composite sponge for rapid and riskless hemostasis
Graphene-kaolin composite sponge for rapid and riskless hemostasis
复制标题
石墨烯-高岭土复合海绵可实现快速、无风险止血
DOI：
10.1016/j.colsurfb.2018.05.016
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发表时间：
2018-09-01
影响因子：
5.8
通讯作者：
Wang, Xing
中科院分区：
文献类型：
--
作者：
Liang, Yuping;Xu, Congcong;Wang, Xing
高岭土是一种安全有效的止血剂。然而，其本体粉末在实际应用中是困难的。为了开发一种实用而强大的止血剂，复合策略通常是一个很好的选择。本文以石墨烯氧化物片、连接剂分子和高岭土粉末为原料，通过水热反应制备了石墨烯-高岭土复合海绵（GKCS）。SEM观察结果支持GKCS具有多孔结构，EDS图谱进一步证实高岭土粉末嵌入石墨烯片中。一旦GKCS暴露于出血，血浆迅速被吸收到海绵内，同时血细胞聚集在界面处。聚集的血细胞有利于加速凝血，这是由于多种刺激，包括浓度、表面电荷和止血因子的活化，其来源于高岭土粉末和石墨烯海绵。结果表明，GKCS在家兔动脉损伤实验中约73 s内止血.此外，细胞毒性和溶血评估表明GKCS具有良好的生物相容性。这些显著的性质表明GKCS是一种潜在的创伤治疗无风险止血剂。(C)2018由Elsevier B. V.出版
Kaolin is an effective and safe hemostatic agent for hemostasis. However, its ontic powder is difficult to use in actual practice. To develop a wieldy and powerful hemostat, composite strategy is usually a good choice. Herein, we developed a graphene-kaolin composite sponge (GKCS), synthesized with graphene oxide sheets, linker molecules and kaolin powders through a facile hydrothermal reaction. SEM observations support that GKCS has a porous structure, and EDS mapping further confirms that kaolin powders are embedded in graphene sheets. Once GKCS is exposed to bleeding, plasma is quickly absorbed inside the sponge, meanwhile blood cells are gathered at the interface. The gathered blood cells are in favor of accelerating clotting due to multi stimulations, including concentration, surface charge and activation of hemostatic factors, originating from both kaolin powders and graphene sponge. As a result, GKCS could stop bleeding in approximately 73 s in rabbit artery injury test. Besides, cytotoxicity and hemolysis assessments highlight that GKCS has a good biocompatibility. These remarkable properties suggest that GKCS is a potential riskless hemostatic agent for trauma treatment. (C) 2018 Published by Elsevier B.V.