Altered sensorimotor cortical oscillations in individuals with multiple sclerosis suggests a faulty internal model
Altered sensorimotor cortical oscillations in individuals with multiple sclerosis suggests a faulty internal model
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DOI：
10.1002/hbm.23644
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发表时间：
2017-08-01
影响因子：
4.8
通讯作者：
Kurz, Max J.
中科院分区：
文献类型：
--
作者：
Arpin, David J.;Heinrichs-Graham, Elizabeth;Kurz, Max J.
多发性硬化症(MS)是一种脱髓鞘疾病，会导致一系列症状，包括运动能力受损。然而，纤维的这种脱髓鞘如何影响运动神经回路中固有的神经生理活动，在很大程度上仍不清楚。潜在地，与MS相关的运动误差可能是由于用于预测将满足任务要求的电机输出的内部模型中的不完善所致。先前的脑磁图(MEG)和脑成像实验已经证实，感觉运动皮质中的β(15-30赫兹)振荡活动与运动控制有关。具体地说，有人提出，运动后贝塔反弹的强度可能表明内部模型的确定性。在这项研究中，我们使用脑磁图来评估多发性硬化症患者和健康人在目标导向的等长膝关节力量任务中感觉运动皮质的神经振荡活动。我们的结果显示，在运动的计划和执行阶段，多发性硬化症患者和健康人之间的β活动没有差别。然而，我们确实发现，与健康对照组相比，多发性硬化症患者在中央前/后回的运动后β反弹较弱。此外，我们发现多发性硬化症患者的行为表现是异常的，并且与运动后β反弹的强度有关。这些结果表明，Hum Brain Mapp 38：4009-4018,2017年的个体的内部模型可能存在缺陷。(C)2017威利期刊公司。
Multiple sclerosis (MS) is a demyelinating disease that results in a broad array of symptoms, including impaired motor performance. How such demyelination of fibers affects the inherent neurophysiological activity in motor circuits, however, remains largely unknown. Potentially, the movement errors associated with MS may be due to imperfections in the internal model used to make predictions of the motor output that will meet the task demands. Prior magnetoencephalographic (MEG) and electroencephalographic brain imaging experiments have established that the beta (15-30 Hz) oscillatory activity in the sensorimotor cortices is related to the control of movement. Specifically, it has been suggested that the strength of the post-movement beta rebound may indicate the certainty of the internal model. In this study, we used MEG to evaluate the neural oscillatory activity in the sensorimotor cortices of individuals with MS and healthy individuals during a goal-directed isometric knee force task. Our results showed no difference between the individuals with MS and healthy individuals in the beta activity during the planning and execution stages of movement. However, we did find that individuals with MS exhibited a weaker post-movement beta rebound in the pre/postcentral gyri relative to healthy controls. Additionally, we found that the behavioral performance of individuals with MS was aberrant, and related to the strength of the post-movement beta rebound. These results suggest that the internal model may be faulty in individuals with MS. Hum Brain Mapp 38:4009-4018, 2017. (c) 2017 Wiley Periodicals, Inc.