Polypeptide N-acetylgalactosaminyltransferase-6 expression in gastric cancer.
Polypeptide N-acetylgalactosaminyltransferase-6 expression in gastric cancer.
复制标题
胃癌中多肽N-乙酰半乳糖氨基转移酶6的表达
DOI：
10.2147/ott.s138590
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发表时间：
2017
影响因子：
4
通讯作者：
Guo H
中科院分区：
文献类型：
--
作者：
Guo Y;Shi J;Zhang J;Li H;Liu B;Guo H
胃癌（GC）是癌症相关死亡的主要原因之一，其临床结果在全球范围内改善有限。异常的粘蛋白型 O-糖基化是 GC 发展中广泛存在的一个关键事件。多肽 N-乙酰半乳糖胺基转移酶 (GALNT) 调节起始步骤并确定粘蛋白型 O-糖蛋白生物合成的位点。 GALNT6 作为多种癌症的生物标志物具有巨大的潜力。分析GALNT6在GC中的作用,结果显示,与癌旁胃组织相比,GC组织中GALNT6的表达量显着升高。肿瘤内高 GALNT6 密度与 TNM 分期和远处转移的临床病理参数相关。 GALNT6被确定为GC患者预后不良的独立预测因子。此外，GALNT6的高表达水平与E-cadherin和β-catenin的低表达水平以及MMP9的高表达水平显着相关。这些发现表明，GALNT6 可以为 GC 的表征提供新的见解，并有助于开发有效的预后指标和新颖的 GC 治疗方式。
Gastric cancer (GC) is one of the leading causes of cancer-related deaths, with limited improvement in its clinical outcome worldwide. Aberrant mucin-type O-glycosylation is a critical event widespread in the development of GC. Polypeptide N-acetylgalactosaminyltransferases (GALNTs) regulate the initial step and determine the sites of mucin-type O-glycoprotein bio-synthesis. GALNT6 has considerable potential as a biomarker in various cancers. The roles of GALNT6 in GC were analyzed, and the results showed that GALNT6 expression markedly increased in GC tissues compared with those in adjacent gastric tissues. High intratumoral GALNT6 density was associated with the clinicopathological parameters of TNM stage and distant metastasis. GALNT6 was identified as an independent prognosticator for the poor prognosis of GC patients. Moreover, the high expression level of GALNT6 was significantly associated with the low expression levels of E-cadherin and β-catenin and the high expression levels of MMP9. These findings indicated that GALNT6 could provide new insights into the characterization of GC as well as contribute to the development of an efficient prognostic indicator and novel therapeutic modalities for GC.