Plasma apolipoprotein pattern in fish-eye disease examined by high-resolution two-dimensional electrophoresis.
Plasma apolipoprotein pattern in fish-eye disease examined by high-resolution two-dimensional electrophoresis.
复制标题
通过高分辨率二维电泳检查鱼眼病中的血浆载脂蛋白模式。
作者：
T. Marshall;K. Williams;L. Holmquist;L. Carlson;O. Vesterberg
我们比较了血浆蛋白模式的两个活生生的患者患有鱼眼病与适当的控制，使用高分辨率的双向电泳。在血浆多肽中检测到对应于载脂蛋白A-I和A-II亚型的定量异常。该疾病的特征是载脂蛋白A-I原浓度正常，但其他载脂蛋白A-I亚型和载脂蛋白A-II浓度显著低于正常。其他血浆蛋白浓度无显著差异。这些研究结果进行了讨论与其他载脂蛋白疾病。
We compared the plasma protein patterns of the two living patients suffering from fish-eye disease with those of appropriate controls, using high-resolution two-dimensional electrophoresis. Quantitative abnormalities were detected in plasma polypeptides corresponding to the isoforms of apolipoproteins A-I and A-II. The disease was characterized by normal concentrations of proapo A-I but dramatically subnormal concentrations of the other apo A-I isoforms and apo A-II. No significant difference was detected in the concentrations of other plasma proteins. These findings are discussed in relation to other apolipoprotein disorders.