Comparison of responses elicited by alpha-thrombin in isolated canine basilar, coronary, mesenteric, and renal arteries.
Comparison of responses elicited by alpha-thrombin in isolated canine basilar, coronary, mesenteric, and renal arteries.
复制标题
比较α-凝血酶在离体犬基底动脉、冠状动脉、肠系膜和肾动脉中引起的反应。
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
J. Robertson
中科院分区：
文献类型：
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作者：
R. White;Y. Shirasawa;J. Robertson
以0.001、0.01、0.1、1.0、10和/或100 U/ml的累积浓度应用α-凝血酶，以测定离体犬动脉环中的峰值反应。α-凝血酶未能引起肠系膜动脉收缩，在肾动脉中产生不一致的效应，并在冠状动脉和基底动脉中产生双相效应（舒张被收缩取代）。在基底动脉中，α-凝血酶引起的舒张被阻断，并且通过扩血管或用加热的凝血酶代替α-凝血酶来增强最大收缩。这些结果支持了以下假设：α-凝血酶作用于基底动脉中的两种不同受体，并参与脑血管痉挛的发病机制。
Alpha-thrombin was applied in cumulative concentrations of 0.001, 0.01, 0.1, 1.0, 10, and/or 100 U/ml to determine peak responses in isolated canine arterial rings. Alpha-thrombin failed to elicit contraction in the mesenteric artery, produced inconsistent effects in the renal artery, and produced biphasic effects (relaxation superseded by contraction) in the coronary and basilar arteries. In the basilar artery the relaxation induced by alpha-thrombin was blocked and the maximal contractions enhanced by reaming the vessel or by substituting heated thrombin for alpha-thrombin. The results support the hypotheses that alpha-thrombin acts on two distinct receptors in the basilar artery and that it is involved in the pathogenesis of cerebral vasospasm.