Intracranial area: A validated method for estimating intracranial volume
Intracranial area: A validated method for estimating intracranial volume
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DOI：
10.1177/1051228404270243
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发表时间：
2005-01-01
影响因子：
2.4
通讯作者：
MacLullich, AMJ
中科院分区：
文献类型：
--
作者：
Ferguson, KJ;Wardlaw, JM;MacLullich, AMJ
背景和目的。控制颅内容积对于脑容量变化的磁共振研究至关重要，然而，完整的颅内容积测量需要长时间的扫描和分析，并且缺乏简单、有效的颅内容积估计方法。作者开发并评估了一种使用单个中矢状切片（颅内横截面积）来估计颅内体积的方法。方法。 40名65-70岁的男性进行了1.9T的全颅骨磁共振扫描，层厚为1.5毫米（无层间隙）。在 3 视图定位器的中线矢状切片中追踪颅内横截面积。使用每个切片测量颅内体积。对十个颅内横截面积测量结果进行了测试，以确保参与者之间的可靠性。结果。颅内横截面积和颅内容量高度相关 (r = .88, P < .0001)。修改后的 Bland-Altman 图显示颅内横截面积和颅内体积之间具有良好的一致性。颅内横截面积的组内相关性（可靠性指标）为 r = .976 (P < .005)。结论。颅内横截面积测量快速而简单的技术提供了颅内体积的有效且可靠的估计。
Background and Purpose. Controlling for intracranial volume is crucial in magnetic resonance studies of changes in brain volumes, However, full intracranial volume measurement requires prolonged scanning and analysis, and simple, validated methods for intracranial volume estimation are lacking. The authors developed and evaluated a method of estimating intracranial volume using a single mid-sagittal slice, the intracranial cross-sectional area. Methods. Forty men aged 65-70 had whole skull magnetic resonance scans at 1.9 T, with slice thickness of 1.5 mm (no interslice gap). Intracranial cross-sectional area was traced in the midline sagittal slice of the 3-view localizer. Intracranial volume was measured using every slice. Ten intracranial cross-sectional area measurements were tested for interrater reliability. Results. Intracranial cross-sectional area and intracranial volume correlated highly (r = .88, P < .0001). A modified Bland-Altman plot showed good agreement between intracranial cross-sectional area and intracranial volume. The intraclass correlation (an indicator of reliability) for intracranial cross-sectional area was r = .976 (P < .005). Conclusions. The rapid and simple technique of intracranial cross-sectional area measurement provides a valid and reliable estimate of intracranial volume.