Development of a linear type of low molecular weight CXCR4 antagonists based on T140 analogs
Development of a linear type of low molecular weight CXCR4 antagonists based on T140 analogs
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DOI：
10.1039/b603818b
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发表时间：
2006-01-01
影响因子：
3.2
通讯作者：
Fujii, Nobutaka
中科院分区：
文献类型：
--
作者：
Tamamura, Hirokazu;Tsutsumi, Hiroshi;Fujii, Nobutaka
基于T140类似物开发了几种线性类型的低分子量CXCR4拮抗剂，这些类似物先前被发现是强CXCR4拮抗剂，可阻断X4-HIV-1进入并对癌症转移/进展和类风湿性关节炎具有抑制活性。
A linear type of several low molecular weight CXCR4 antagonists were developed based on T140 analogs, which were previously found to be strong CXCR4 antagonists that block X4-HIV-1 entry and have inhibitory activities against cancer metastasis/progression and rheumatoid arthritis.