Optimal control of directional deep brain stimulation in the parkinsonian neuronal network
Optimal control of directional deep brain stimulation in the parkinsonian neuronal network
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DOI：
10.1016/j.cnsns.2015.12.005
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发表时间：
2016-07-01
影响因子：
3.9
通讯作者：
Wang, Qingyun
中科院分区：
文献类型：
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作者：
Fan, Denggui;Wang, Zhihui;Wang, Qingyun
传统的脑深部电刺激（DBS）对帕金森病的衰弱症状的影响可能是有限的，因为它只能产生球形场。并且，一些副作用明显地通过影响其邻近神经节而引起。最近针对帕金森病患者的实验证据表明，具有32个独立刺激源触点的新型DBS电极在应用于丘脑底核（subthalamic nucleus，简称DBS）时，可以通过扩大治疗窗口来有效优化临床治疗。这是由于在各种刺激触点的集群中的选择性激活，这些刺激触点可以在感兴趣的目标区域上被定向和准确地操纵。此外，由于对神经组织的严重损伤，通常不指示电荷不平衡刺激，并且真实的DBS利用电荷平衡双相（CBBP）脉冲。受此启发，我们计算研究定向CBBP-DBS的最佳控制从建议的帕金森神经元网络的基底节-丘脑皮质回路。通过对不同神经元群体进行适当的调节刺激，可以发现定向引导CBBP-DBS范式在改善帕金森病动力学特性方面上级球形情况，包括神经元群体的同步性和丘脑传递来自皮层的信息的可靠性，这与生理实验结果吻合得很好。此外，可以发现，与球形情况相比，定向转向刺激可以将去极化的最佳刺激强度增加超过1 mA。这与实验结果一致，表明至少存在一个转向方向可以允许将副作用阈值提高1 mA。此外，我们还模拟了局部场电位（LFP）和主频率（DF）的32个不同的接触，以最佳的刺激强度和刺激后立即，分别激活所诱导的ESTA神经元群体。这些结果可以揭示丘脑核团内病理活动的区域性差异。结果表明，与实验结果一致，定向转向刺激可诱发低幅值的LFP，这意味着去极化区的出现，DF的分布可位于β频率范围的13-40 Hz。本研究结果可望为探讨脑的病理生理活动提供理论依据。(C)2015爱思唯尔B. V.保留所有权利。
The effect of conventional deep brain stimulation (DBS) on debilitating symptoms of Parkinson's disease can be limited because it can only yield the spherical field. And, some side effects are clearly induced with influencing their adjacent ganglia. Recent experimental evidence for patients with Parkinson's disease has shown that a novel DBS electrode with 32 independent stimulation source contacts can effectively optimize the clinical therapy by enlarging the therapeutic windows, when it is applied on the subthalamic nucleus (STN). This is due to the selective activation in clusters of various stimulation contacts which can be steered directionally and accurately on the targeted regions of interest. In addition, because of the serious damage to the neural tissues, the charge-unbalanced stimulation is not typically indicated and the real DBS utilizes charge-balanced bi-phasic (CBBP) pulses. Inspired by this, we computationally investigate the optimal control of directional CBBP-DBS from the proposed parkinsonian neuronal network of basal ganglia-thalamocortical circuit. By appropriately tuning stimulation for different neuronal populations, it can be found that directional steering CBBP-DBS paradigms are superior to the spherical case in improving parkinsonian dynamical properties including the synchronization of neuronal populations and the reliability of thalamus relaying the information from cortex, which is in a good agreement with the physiological experiments. Furthermore, it can be found that directional steering stimulations can increase the optimal stimulation intensity of desynchronization by more than 1 mA compared to the spherical case. This is consistent with the experimental result with showing that there exists at least one steering direction that can allow increasing the threshold of side effects by 1 mA. In addition, we also simulate the local field potential (LFP) and dominant frequency (DF) of the STN neuronal population induced by the activation of 32 different contacts with optimal stimulation intensity and immediately after the stimulation, respectively. These can reveal regional differences in pathological activity within STN nucleus. It is shown that in line with the experimental results directional steering stimulation can induce the low-amplitude LFP which implies the occurrence of desynchronizing regime, as well as the distribution of DF can locate at the 13-40 Hz of beta frequency range. Hopefully, the obtained results can provide theoretical evidences in exploring pathophysiologic activity of brain. (C) 2015 Elsevier B.V. All rights reserved.