Amino acid solutions for premature neonates during the first week of life: the role of N-acetyl-L-cysteine and N-acetyl-L-tyrosine.
Amino acid solutions for premature neonates during the first week of life: the role of N-acetyl-L-cysteine and N-acetyl-L-tyrosine.
复制标题
早产儿出生第一周的氨基酸溶液：N-乙酰基-L-半胱氨酸和 N-乙酰基-L-酪氨酸的作用。
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
P. Sauer
中科院分区：
文献类型：
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作者：
J. B. V. Goudoever;E. Sulkers;M. Timmerman;J.G.M. Huijmans;Klaus Langer;V. Carnielli;P. Sauer
酪氨酸和半胱氨酸被认为是早产儿必需的氨基酸。这些氨基酸具有低稳定性（半胱氨酸）或低溶解度（酪氨酸），因此通常仅少量存在于氨基酸溶液中。乙酰化提高了氨基酸的稳定性和溶解度，有利于溶液中更高的浓度。我们比较了三种市售氨基酸溶液：Aminovenös-N-päd 10%、Vaminolact 6.5% 和 Primène 10%，对 20 名低出生体重新生儿从出生后第 2 天起进行全肠外营养给药。 Aminovenös-N-päd 10% 含有乙酰化酪氨酸和乙酰化半胱氨酸；其他溶液不含乙酰化氨基酸，并且酪氨酸和半胱氨酸的添加量不同。出生后第7天，测定血浆氨基酸、尿氨基酸排泄量和总氮排泄量；摄入的N-乙酰-L-酪氨酸的38%和N-乙酰-L-半胱氨酸的摄入量的53%通过尿液排出。 N-乙酰基-L-酪氨酸（331+/-74μmol/L）和N-乙酰基-L-半胱氨酸（18+/-29μmol/L）的血浆水平分别高于酪氨酸（105+/-108μmol/L）和胱氨酸（11+/-9μmol/L）。接受少量酪氨酸的组的血浆酪氨酸水平仍然略低于参考范围。我们发现血浆胱氨酸与半胱氨酸的摄入量呈线性相关（r = .75，p = 0.01），但与 N-乙酰基-L-半胱氨酸则不然。半胱氨酸的估计摄入量应为 500 mumol.kg-1.d-1，以获得与正常足月、母乳喂养的新生儿相当的水平。三组之间的氮保留没有差异（247 至 273 mg.kg-1.d-1）。（摘要截断为 250 字）
Tyrosine and cyst(e)ine are amino acids that are thought to be essential for preterm neonates. These amino acids have low stability (cyst(e)ine) or low solubility (tyrosine) and are therefore usually present only in small amounts in amino acid solutions. Acetylation improves the stability and solubility of amino acids, facilitating a higher concentration in the solution. We compared three commercially available amino acid solutions, Aminovenös-N-päd 10%, Vaminolact 6.5%, and Primène 10%, administered to 20 low-birth-weight neonates on total parenteral nutrition from postnatal day 2 onward. Aminovenös-N-päd 10% contains acetylated tyrosine and acetylated cysteine; the other solutions do not contain acetylated amino acids and differ in the amount of tyrosine and cysteine added. On postnatal day 7, plasma amino acids were measured together with urinary excretion of amino acids and the total nitrogen excretion; 38% of the intake of N-acetyl-L-tyrosine and 53% of the intake of N-acetyl-L-cysteine were excreted in urine. Plasma levels of N-acetyl-L-tyrosine (331 +/- 74 mumol/L) and N-acetyl-L-cysteine (18 +/- 29 mumol/L) were higher than those of tyrosine (105 +/- 108 mumol/L) and cystine (11 +/- 9 mumol/L), respectively. Plasma tyrosine levels in the groups receiving small amounts of tyrosine remained just below the reference range. We show a linear correlation of plasma cystine with the intake of cysteine (r = .75, p = 0.01), but not with N-acetyl-L-cysteine. The estimated intake of cysteine should be 500 mumol.kg-1.d-1 in order to obtain levels comparable with those shown in normal term, breast-fed neonates. Nitrogen retention did not differ among the three groups (247 to 273 mg.kg-1.d-1).(ABSTRACT TRUNCATED AT 250 WORDS)
使用肽作为肠外营养底物的实验基础：综述。
DOI：
10.1016/0026-0495(87)90140-5
发表时间：
1987
期刊：
Metabolism: clinical and experimental
影响因子：
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作者：
Adibi,SA
通讯作者：
Adibi,SA