A novel role in cytokinesis reveals a housekeeping function for the unfolded protein response
A novel role in cytokinesis reveals a housekeeping function for the unfolded protein response
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DOI：
10.1083/jcb.200702101
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发表时间：
2007-06-18
影响因子：
7.8
通讯作者：
Niwa, Maho
中科院分区：
文献类型：
--
作者：
Bicknell, Alicia A.;Babour, Anna;Niwa, Maho
未折叠蛋白反应（UPR）途径通过激活增加内质网（ER）功能的基因来帮助细胞科普ER应激。我们已经确定了UPR途径在促进芽殖酵母胞质分裂中的新作用。虽然其他细胞周期事件不受破坏ER功能的条件的影响，但胞质分裂对这些条件敏感。此外，即使在无应激生长条件下，有效的胞质分裂也需要UPR途径。UPR缺陷细胞在胞质分裂中有缺陷，胞质分裂突变体激活UPR。UPR可能通过感知ER负荷的微小变化并使ER容量发生相应的变化来实现其在胞质分裂中的作用。我们提出，胞质分裂是许多细胞的事件，需要一个微妙的增加ER功能和UPR途径有一个以前未表征的管家在正常细胞生长过程中维持ER可塑性的作用之一。
T he unfolded protein response ( UPR) pathway helps cells cope with endoplasmic reticulum ( ER) stress by activating genes that increase the ER's functional capabilities. We have identified a novel role for the UPR pathway in facilitating budding yeast cytokinesis. Although other cell cycle events are unaffected by conditions that disrupt ER function, cytokinesis is sensitive to these conditions. Moreover, efficient cytokinesis requires the UPR pathway even during unstressed growth conditions. UPR-deficient cells are defective in cytokinesis, and cytokinesis mutants activate the UPR. The UPR likely achieves its role in cytokinesis by sensing small changes in ER load and making according changes in ER capacity. We propose that cytokinesis is one of many cellular events that require a subtle increase in ER function and that the UPR pathway has a previously uncharacterized housekeeping role in maintaining ER plasticity during normal cell growth.