Circadian modulation of Fos responses to odor of the red fox, a rodent predator, in the rat olfactory system
Circadian modulation of Fos responses to odor of the red fox, a rodent predator, in the rat olfactory system
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DOI：
10.1016/s0006-8993(00)02249-6
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发表时间：
2000-06-02
期刊：
影响因子：
2.9
通讯作者：
Amir, S
中科院分区：
文献类型：
--
作者：
Funk, D;Amir, S
我们之前已经证明，在嗅觉系统中，神经元对生物中性气味雪松木油的反应在主观夜晚比主观白天更大。在这项研究中，我们证实了这些结果，并将其扩展到一种生物学上相关的气味--红狐的尿液，这是一种啮齿动物捕食者。与主观白天相比，暴露在狐狸尿液或中性气味矿物油中的大鼠在主嗅球、初级嗅皮层和其他与嗅觉有关的结构中诱导的FOS在主观夜晚显著增强。这些结果表明，神经元对行为学上相关的气味的反应遵循与生物中性气味相似的昼夜节律。在涉及恐惧反应的大脑区域，观察到狐狸尿液诱导的FOS反应比中性气味更大，这表明狐狸尿液激活了恐惧回路。(C)2000 Elsevier Science B.V.保留所有权利。
We have previously shown that neuronal responses to a biologically neutral odor, cedar wood oil, in the olfactory system are greater in the subjective night compared to subjective day. in the present study, we confirm these results and extend them to a biologically relevant odor, the urine of the red fox, a rodent predator. Fos induced by exposure of rats to fox urine or a neutral odor, mineral oil, was markedly enhanced during the subjective night compared to subjective day in the main olfactory bulb, primary olfactory cortex, and other structures related to olfaction. These results show that neuronal responses to an ethologically relevant odor follow a circadian rhythm similar to biologically neutral odors. Fos responses induced by fox urine were observed to be of greater magnitude than a neutral odor in brain areas involved in fear responses, suggesting that fox urine activates fear circuitry. (C) 2000 Elsevier Science B.V. All rights reserved.