The endocannabinoid signalling system: Biochemical aspects
The endocannabinoid signalling system: Biochemical aspects
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DOI：
10.1016/j.pbb.2005.01.027
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发表时间：
2005-06-01
影响因子：
3.6
通讯作者：
Di Marzo, V
中科院分区：
文献类型：
--
作者：
Bisogno, T;Ligresti, A;Di Marzo, V
在过去的几年里，关于内源性大麻素系统的知识有了很大的扩展。在发现大麻素受体及其内源性激动剂以及合成和失活大麻素的蛋白质之后，在理解内源性大麻素系统在生命功能中的作用方面取得了重大进展。随后，越来越多的关于内源性大麻素的生物化学和药理学的论文发表。本文综述了内源性大麻素信号系统及其生化方面的研究进展。特别是，我们综述了内源性大麻素的生物合成和失活机制，以及到目前为止所描述的一些内源性大麻素的各种分子靶标。(C)2005 Elsevier Inc.保留所有权利。
Knowledge of the endogenous cannabinoid system has expanded greatly during the past years. After the discovery of the cannabinoid receptors, of their endogenous agonists and of the proteins for their synthesis and inactivation, significant progress has been made towards the understanding of the role of the endocannabinoid system in vital functions. Subsequently, an increasing number of papers has been published on the biochemistry and pharmacology of endocannabinoids. This article overviews the endocannabinoid signalling system with focus on its biochemical aspects. In particular we review the mechanisms for the biosynthesis and inactivation of the endocannabinoids, as well as the various molecular targets for some of the endocannabinoids described so far. (c) 2005 Elsevier Inc. All rights reserved.