PLANT DEVELOPMENT Integration of growth and patterning during vascular tissue formation in Arabidopsis
PLANT DEVELOPMENT Integration of growth and patterning during vascular tissue formation in Arabidopsis
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DOI：
10.1126/science.1255215
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发表时间：
2014-08-08
期刊：
影响因子：
56.9
通讯作者：
Weijers, Dolf
中科院分区：
文献类型：
--
作者：
De Rybel, Bert;Adibi, Milad;Weijers, Dolf
细胞分裂和图案形成的协调是组织和器官发育的核心，特别是在植物中，细胞壁阻止细胞迁移。生长素和细胞分裂素都对分裂和图案化至关重要，但这些激素如何在组织发育中聚集尚不清楚。我们确定了一个遗传网络，加强了早期胚胎的偏见生长素分布，创造一个本地的，无反应的细胞分裂素来源内的根维管组织。实验和理论证据表明，这些细胞通过定位定向细胞分裂的域来充当组织者。我们进一步证明，生长素-细胞分裂素的相互作用作为一个空间不连贯的前馈回路，这是必不可少的产生不同的激素反应区，从而建立一个稳定的模式内不断增长的血管组织。
Coordination of cell division and pattern formation is central to tissue and organ development, particularly in plants where walls prevent cell migration. Auxin and cytokinin are both critical for division and patterning, but it is unknown how these hormones converge upon tissue development. We identify a genetic network that reinforces an early embryonic bias in auxin distribution to create a local, nonresponding cytokinin source within the root vascular tissue. Experimental and theoretical evidence shows that these cells act as a tissue organizer by positioning the domain of oriented cell divisions. We further demonstrate that the auxin-cytokinin interaction acts as a spatial incoherent feed-forward loop, which is essential to generate distinct hormonal response zones, thus establishing a stable pattern within a growing vascular tissue.