EFFECTS OF MENSTRUAL AND REPRODUCTIVE FACTORS ON THE RISK OF BREAST-CANCER - METAANALYSIS OF THE CASE-CONTROL STUDIES IN JAPAN
EFFECTS OF MENSTRUAL AND REPRODUCTIVE FACTORS ON THE RISK OF BREAST-CANCER - METAANALYSIS OF THE CASE-CONTROL STUDIES IN JAPAN
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DOI：
10.1111/j.1349-7006.1995.tb03000.x
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发表时间：
1995-10-01
期刊：
影响因子：
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通讯作者：
SHIMIZU, H
中科院分区：
文献类型：
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作者：
NAGATA, C;HU, YH;SHIMIZU, H
为了阐明月经和生殖因素对日本女性乳腺癌发生的影响程度，我们回顾了之前在日本进行的八项病例对照研究，并使用定量方法（荟萃分析）来总结数据。虽然个别研究有不同的方法和人群，但研究中所有研究变量的估计比值比 (OR) 在统计上是同质的。研究证实，初潮年龄早、初产年龄晚、绝经前状态与乳腺癌风险显着相关；与 14 岁之前开始月经的女性相比，16 岁之后开始月经的女性的估计综合 OR 为 0.68（95% 置信区间 (CI) 0.59-0.77）。未生育的女性比 25 岁之前第一次生育的女性风险更高（OR = 1.56 95%，CI：1.27-191）。与 25 岁之前第一次生育的女性相比，35 岁之后第一次生育的女性的 OR 为 2.26（95% CI：1.85-2.77）。绝经前女性比 50 岁之前绝经的女性风险更高（OR = 2.21，95% CI：1.53-320）。在控制初产年龄和其他月经因素后，我们还发现高胎次具有显着的保护作用。与未生育相比，生育 3 次或以上的 OR 估计值为 0.68（95% CI：0.54-0.86）。该荟萃分析提供了日本女性乳腺癌风险的定量估计，且精度更高。
To elucidate the magnitude of the effect of menstrual and reproductive factors on breast cancer occurrence among Japanese women, we reviewed eight case-control studies previously conducted in Japan and used a quantitative method (meta-analysis) to summarize the data. While individual studies have different methods and populations, the estimated odds ratios (ORs) in the studies were statistically homogeneous for all study variables. It was confirmed that early age at menarche, late age at first birth, and premenopausal status are significantly associated with risk of breast cancer; an estimated combined OR of 0.68 (95% confidence interval (CI) 0.59-0.77) was obtained for women with onset of menstruation after age 16 compared to those before age 14. Nulliparous women had higher risk than women with first birth before age 25 (OR = 1.56 95%, CI: 1.27-191). The OR for women with first birth after age 35 was 2.26 (95% CI: 1.85-2.77) compared to women at first birth before age 25. Premenopausal women had a higher risk than women with menopause before age 50 (OR = 2.21, 95% CI: 1.53-320). We also found a significant protective effect of high parity after controlling for age at first birth and the other menstrual factors. The OR estimate for 3 or more births compared to nulliparity was 0.68 (95% CI: 0.54-0.86). The meta-analysis provided quantitative estimates of breast cancer risk among Japanese women with improved precision.