Early life adversity and adult biological risk profiles.
Early life adversity and adult biological risk profiles.
复制标题
DOI：
10.1097/psy.0000000000000147
复制
发表时间：
2015-02
影响因子：
3.3
通讯作者：
Seeman TE
中科院分区：
文献类型：
--
作者：
Friedman EM;Karlamangla AS;Gruenewald TL;Koretz B;Seeman TE
确定是否有早期生活逆境（ELA）和已知的预测健康风险的生物参数之间的关系，并检查在何种程度上的情况下，在中年介导这种关系。我们分析了来自美国中年发展全国调查（MIDUS）研究第二波生物标志物子样本的1，180名受访者的数据。ELA评估基于儿童社会经济劣势（即福利，感知低收入，受教育程度低的父母）和其他压力因素（例如，父母死亡、父母离婚和父母身体虐待）。结果变量是累积的非稳态负荷（AL），生物风险的标志物。我们还纳入有关成人情况的信息，包括：教育，社会关系和健康行为。儿童期社会经济逆境与AL（B=0.094，SE=0.041）和身体虐待（B=0.263，SE=0.091）增加相关，与父母离婚和死亡无显著关联。成人教育介导的社会经济ELA和累积非稳态负荷之间的关系，以点的非显着性，这个因素单独解释了近40%的关系。儿童期身体虐待和AL之间的关联仍然存在，即使调整成人教育程度，社会关系和健康行为。这些关联在继发性应激系统中最为明显，包括炎症、心血管功能和脂质代谢。早期生活的社会经济逆境的生理后果是通过实现高水平的学校教育后衰减，另一方面，儿童身体虐待的不良后果，坚持在多变量调整分析。
To determine whether there is a relationship between early life adversity (ELA) and biological parameters known to predict health risks and to examine the extent to which circumstances in midlife mediate this relationship. We analyzed data on 1,180 respondents from the biomarker subsample of the second wave of the National Survey of Midlife Development in the United States (MIDUS) study. ELA assessments were based on childhood socioeconomic disadvantage (i.e. on welfare, perceived low income, less-educated parents) and other stressors (e.g., parental death, parental divorce, and parental physical abuse). The outcome variable was cumulative allostatic load (AL), a marker of biological risk. We also incorporate information on adult circumstances, including: education, social relationships, and health behaviors. Childhood socioeconomic adversity was associated with increased AL (B=0.094, SE=0.041) and physical abuse (B=0.263, SE=0.091), with non-significant associations for parental divorce and death. Adult education mediated the relationship between socioeconomic ELA and cumulative allostatic load to the point of non-significance, with this factor alone explaining nearly 40% of the relationship. The association between childhood physical abuse and AL remained even after adjusting for adult educational attainments, social relationships, and health behaviors. These associations were most pronounced for secondary stress systems, including inflammation, cardiovascular function, and lipid metabolism. The physiological consequences of early life socioeconomic adversity are attenuated by achieving high levels of schooling later on. The adverse consequences of childhood physical abuse, on the other hand, persist in multivariable adjusted analysis.