Increased serum bile acids as a possible biomarker of hepatotoxicity in Brazilian workers exposed to solvents in car repainting shops
Increased serum bile acids as a possible biomarker of hepatotoxicity in Brazilian workers exposed to solvents in car repainting shops
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DOI：
10.1080/13547500500399979
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发表时间：
2005-11-01
期刊：
影响因子：
2.6
通讯作者：
De Siqueira, MEPB
中科院分区：
文献类型：
--
作者：
De Paiva, MJN;De Siqueira, MEPB
目的是评估血清总胆汁酸（SBA）作为接触有机溶剂的汽车油漆工肝毒性的生物标志物，并将其性能与肝功能的经典生化参数进行比较。对职业接触有机溶剂混合物的选定工人组 (n = 57) 和对照组 (n = 51) 进行了 SBA 分析。此外，还测定了两组的天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、总胆红素（TB）、γ-谷氨酰转移酶（GGT）和碱性磷酸酶（ALP）。测量所有样品中的尿马尿酸。数据统计分析显示，与对照组相比，接触过的工人中 SBA、AST、ALP 和 TB 的浓度显着增加（Mann - Whitney，p
The objective was to evaluate total serum bile acids (SBA) as a biological marker of hepatotoxicity in car painters exposed to organic solvents and to compare their performance with classic biochemical parameters of liver function. SBA were analysed in a selected group of workers (n = 57) occupationally exposed to a mixture of organic solvents and in a control group ( n = 51). In addition, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin ( TB), gamma-glutamyltransferase (GGT) and alkaline phosphatase ( ALP) were determined in the two groups. Urinary hippuric acid was measured in all samples. Statistical analysis of the data revealed a significant increase in the concentration of SBA, AST, ALP and TB in exposed workers compared with controls ( Mann - Whitney, p