Assessment of control strategies against Clonorchis sinensis infection based on a multi-group dynamic transmission model
Assessment of control strategies against Clonorchis sinensis infection based on a multi-group dynamic transmission model
复制标题
基于多群体动态传播模型的华支睾吸虫感染控制策略评估
DOI：
10.1371/journal.pntd.0008152
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发表时间：
2020-03-01
影响因子：
3.8
通讯作者：
Lai, Ying-Si
中科院分区：
文献类型：
--
作者：
Huang, Xiao-Hong;Qian, Men-Bao;Lai, Ying-Si
华支睾吸虫病是影响数百万人的最重要的食源性吸虫病之一。不同的组织建议了战略，并执行了控制方案，但大多是在短期内。重要的是要评估可能的控制策略对疾病发病率控制的长期效益和可持续性。我们建立了一个多群传播模型来描述C。在此基础上，提出了一个完整的干预模型，并提出了三种常用的控制措施（即，预防性化疗、信息、教育和交流（IEC）以及环境改造）及其可能的组合。在典型的C.针对中华绒螯蟹的传播，我们模拟了不同策略下的干预，并设定了一系列干预参数。研究发现，多项措施的组合效果优于单一措施;措施覆盖率越高，效果越好;针对全体人群的策略效果优于针对有生鱼消费行为的高危人群的策略。中国广东省政府推荐的策略显示出良好且可持续的效果，在该策略下，感染控制（以人类流行
Clonorchiasis is one of the most important food-borne trematodiases affecting millions of people. Strategies were recommended by different organizations and control programmes were implemented but mostly in short-time periods. It's important to assess the long-term benefits and sustainability of possible control strategies on morbidity control of the disease. We developed a multi-group transmission model to describe the dynamics of C. sinensis transmission among different groups of people with different raw-fish-consumption behaviors, based on which, a full model with interventions was proposed and three common control measures (i.e., preventive chemotherapy, information, education, and communication (IEC) and environmental modification) and their possible combinations were considered. Under a typical setting of C. sinensis transmission, we simulated interventions according to different strategies and with a series of values of intervention parameters. We found that combinations of measures were much beneficial than those singly applied; higher coverages of measures had better effects; and strategies targeted on whole population performed better than that on at-risk population with raw-fish-consumption behaviors. The strategy recommended by the government of Guangdong Province, China shows good and sustainable effects, under which, the infection control (with human prevalence