The Role of Long Non-coding RNAs in Sepsis-Induced Cardiac Dysfunction.
The Role of Long Non-coding RNAs in Sepsis-Induced Cardiac Dysfunction.
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长非编码 RNA 在脓毒症引起的心脏功能障碍中的作用
DOI：
10.3389/fcvm.2021.684348
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发表时间：
2021
影响因子：
3.6
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Li J;Zhang Y;Zhang D;Li Y
脓毒症是一种由宿主对感染的反应失调引起的危及生命的器官功能障碍综合征。心脏是脓毒症期间最常累及的器官之一，并且心功能障碍通常指示极差的临床结果，是脓毒症病例中死亡的主要原因。尽管对脓毒症的起源和反应机制的理解有了很大的提高，但脓毒症诱导的心功能不全（SICD）的预后仍然很差，其分子病理生理学变化尚未得到很好的表征。最近发现的一组称为长链非编码RNA（lncRNA）的介质为探索SICD的机制和发展提供了新的见解和机会，并可能为诊断和治疗策略提供新的靶点。lncRNA是超过200个核苷酸的RNA转录物，具有有限的或没有蛋白质编码潜力。从大量的研究中已经迅速积累了关于lncRNA如何在SICD期间相关调节回路中发挥作用的证据。本文综述了基于临床试验和动物研究的lncRNA对SICD影响的直接证据。此外，总结了脓毒症研究中发现的SICD中潜在的功能性lncRNA，并在其他心血管疾病的研究中证实了其生物学功能。
Sepsis is a syndrome with life-threatening organ dysfunction induced by a dysregulated host response to infection. The heart is one of the most commonly involved organs during sepsis, and cardiac dysfunction, which is usually indicative of an extremely poor clinical outcome, is a leading cause of death in septic cases. Despite substantial improvements in the understanding of the mechanisms that contribute to the origin and responses to sepsis, the prognosis of sepsis-induced cardiac dysfunction (SICD) remains poor and its molecular pathophysiological changes are not well-characterized. The recently discovered group of mediators known as long non-coding RNAs (lncRNAs) have presented novel insights and opportunities to explore the mechanisms and development of SICD and may provide new targets for diagnosis and therapeutic strategies. LncRNAs are RNA transcripts of more than 200 nucleotides with limited or no protein-coding potential. Evidence has rapidly accumulated from numerous studies on how lncRNAs function in associated regulatory circuits during SICD. This review outlines the direct evidence of the effect of lncRNAs on SICD based on clinical trials and animal studies. Furthermore, potential functional lncRNAs in SICD that have been identified in sepsis studies are summarized with a proven biological function in research on other cardiovascular diseases.