Effects of interleukin-1 gene polymorphisms on the development of coronary artery disease associated with Chlamydia pneumoniae infection
Effects of interleukin-1 gene polymorphisms on the development of coronary artery disease associated with Chlamydia pneumoniae infection
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DOI：
10.1016/s0735-1097(01)01438-3
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发表时间：
2001-09-01
影响因子：
24
通讯作者：
Ohsuzu, F
中科院分区：
文献类型：
--
作者：
Momiyama, Y;Hirano, R;Ohsuzu, F
目的本研究旨在阐明白细胞介素（IL）-1基因多态性对肺炎衣原体（CP）感染相关的冠状动脉疾病（CAD）的影响。然而，在这方面，与CP感染相关的CAD的遗传因素尚不清楚。方法我们评估了CP免疫球蛋白G（IgG）血清阳性和IL-1 β（-511处的C/T转换）和IL-1受体拮抗剂（IL-1 Ra）结果292例冠状动脉造影患者中CP血清学阳性率为61%，CAD患者与非CAD患者的51%（p = NS）。冠心病患者中IL-1 β（-511）C/C基因型和/或IL-1 Ra（内含子2）2-或3-重复等位基因的患者百分比高于非冠心病患者（29 vs. 16%，p < 0.025）。为了阐明这些CAD相关变体（IL-1 β C/C和/或IL-1 Ra 2-或3-重复）的影响，将患者分为四组。根据CP血清阳性和变异，观察到CAD患病率逐步增加。CAD的比值比（OR）在单独血清阳性组中为1.4，单独变异组为1.7，血清阳性和变异组为3.8。在血清阳性和非血清阳性患者中，这些变异与CAD相关。有趣的是，心肌梗死（MI）的高患病率仅限于血清阳性和变异组（OR，2.8）。结论IL-1基因多态性在CP感染患者中与CAD，尤其是MI的发生发展有关。(C)2001年，美国心脏病学会。
OBJECTIVES This study was done to elucidate the effects of interleukin (IL)-1 gene polymorphisms on coronary artery disease (CAD) associated with Chlamydia pneumoniae (CP) infection.BACKGROUND It was suggested that CP was associated with CAD. However, genetic factors involved in CAD associated with CP infection are unknown.METHODS We evaluated CP immunoglobulin G (IgG) seropositivity and IL-1 beta (a C/T transition at -511) and IL-1 receptor antagonist (IL-1Ra) (a variable-number repeat in intron 2) gene polymorphisms in 292 patients undergoing coronary angiography.RESULTS Seropositivity for CP was present in 61% of patients with CAD versus 51% without CAD (p = NS). The percentage of patients having IL-1 beta (-511) C/C genotype and/or IL-1Ra (intron 2) 2- or 3-repeat allele was higher in patients with CAD than without CAD (29 vs. 16%, p < 0.025). To clarify the effects of these CAD-associated variants (IL-1 beta C/C and/or IL-1Ra 2- or 3-repeat), patients were divided into four groups. A stepwise increase in CAD prevalence was observed depending on CP seropositivity and the variants. Odds ratios (ORs) for CAD were 1.4 in the group with seropositivity alone, 1.7 with the variants alone and 3.8 with seropositivity and the variants. Such variants were associated with CAD in both patients with and without seropositivity. Interestingly, high prevalence of myocardial infarction (MI) was confined to the group with seropositivity and the variants (OR, 2.8). The variants were associated with MI only in patients with CP seropositivity.CONCLUSIONS The IL-1 gene polymorphisms were found to play a role in the development of CAD, especially MI, in patients with CP infection. (C) 2001 by the American College of Cardiology.