Granulocytic sarcoma of breast: an aleukemic presentation.
Granulocytic sarcoma of breast: an aleukemic presentation.
复制标题
乳腺粒细胞肉瘤：白血病表现。
DOI：
10.4103/0019-5359.30750
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Y. Patil
中科院分区：
文献类型：
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作者：
G. D'costa;M. Hastak;Y. Patil
粒细胞肉瘤是一种罕见的髓外肿瘤，由未成熟的骨髓细胞组成。它通常与白血病或其他骨髓增生性疾病有关，但也可以在没有明显血液病的情况下发生。乳房是一个不常见的网站介绍，并要求高度怀疑诊断。我们报告一个45岁女性的病例，她以无压痛的左侧乳房肿块来表现，持续了6个月。当时外周血涂片和骨髓检查正常。进行了乳房肿瘤切除术。考虑了小叶癌与非霍奇金淋巴瘤的H和E诊断。免疫组化显示髓过氧化物酶、萘酚AS-D氯乙酸酯酶和CD 43阳性，提示粒细胞肉瘤的诊断。看来，早期开始全身AML型化疗是有益的，并可能延迟或避免骨髓和血液中AML的发展。8个月后，患者出现眼眶肿块; AML累及骨髓和外周涂片。
Granulocytic sarcoma is a rare extramedullary tumor composed of immature myeloid cells. It is usually associated with leukemia or other myeloproliferative disorders but can also occur without overt hematologic diseases. The breast is an uncommon site of presentation and requires a high index of suspicion for diagnosis. We report such a case in a 45-year-old female, who presented with nontender left breast lump of 6 months' duration. A peripheral smear and bone marrow examination at that time was normal. A lumpectomy was done. An H and E diagnosis of lobular carcinoma vs. non-Hodgkin's lymphoma was entertained. Immunostains, however, revealed myeloperoxidase, naphthol AS-D chloroacetate esterase and CD43 positivity, indicating a diagnosis of granulocytic sarcoma. It appears that early initiation of systemic AML-type chemotherapy is beneficial and may delay or avert the development of AML in bone marrow and blood. Eight months later, the patient presented with an orbital mass; bone marrow and peripheral smear involvement by AML.