Cloning and characterization of myr 6, an unconventional myosin dilute/myosin-V family
Cloning and characterization of myr 6, an unconventional myosin dilute/myosin-V family
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DOI：
10.1073/pnas.93.20.10826
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发表时间：
1996-10-01
影响因子：
11.1
通讯作者：
Mercer, JA
中科院分区：
文献类型：
--
作者：
Zhao, LP;Koslovsky, JS;Mercer, JA
我们已经分离出编码第二个成员的cDNA，（肌球蛋白-V）脊椎动物中的非常规肌球蛋白家族，myr 6（来自大鼠6的肌球蛋白），myr 6转录物在脑中的表达比稀释的表达有限得多，在脉络丛和边缘系统的组分中观察到最高水平。我们已经使用种间回交将myr 6基因座定位到小鼠18号染色体，来自大鼠的myr 6 cDNA序列的3'部分与先前公布的来自小鼠的假定谷氨酸脱羧酶的3'部分几乎相同[Huang，W. M.，里德-富尔凯湖Wu，E. & Wu，J. Y.等人（1990）Proc. Acad. Sci. USA 87，8491-8495]。
We have isolated cDNAs encoding a second member of the dilute (myosin-V) unconventional myosin family in vertebrates, myr 6 (myosin from rat 6), Expression of myr 6 transcripts in the brain is much more limited than is the expression of dilute, with highest levels observed in choroid plexus and components of the limbic system, We have mapped the myr 6 locus to mouse chromosome 18 using an interspecific backcross, The 3' portion of the myr 6 cDNA sequence from rat is nearly identical to that of a previously published putative glutamic acid decarboxylase from mouse [Huang, W. M., Reed-Fourquet, L., Wu, E. & Wu, J. Y. (1990) Proc. Natl. Acad. Sci. USA 87, 8491-8495].