Acute dystonic reaction with low-dose pimozide.
Acute dystonic reaction with low-dose pimozide.
复制标题
小剂量匹莫齐特引起急性肌张力障碍反应。
DOI：
10.1097/00004583-199305000-00022
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发表时间：
1993
影响因子：
13.3
通讯作者：
Campbell,M
中科院分区：
文献类型：
--
作者：
Ernst,M;Gonzalez,NM;Campbell,M
认识到个体对抗精神病药引起的副作用的易感性对于治疗指南是至关重要的。本文报告1例6.9岁男性自闭症患者，在停药32小时后及随后服用硫代咪嗪期间反复出现与剂量为0.096 mg/kg/d和0.032 mg/kg/d的吡莫齐特相关的急性肌张力障碍反应。它提请临床医生注意对惊厥类副作用的异常敏感性，并表明如果儿童对一种抗精神病药物表现出这种敏感性，他/她可能也会对其他抗精神病药物产生类似的反应。阿卡德。青春期儿童。精神病学，1993，32，3：640-642。
It is essential to recognize individual susceptibility to neuroleptic-induced side effects for treatment guidelines. This paper reports on a 6.9-year-old autistic male who developed repeated episodes of acute dystonic reactions associated with pimozide administration at the doses of 0.096 mg/kg/day and 0.032 mg/kg/day and 32 hours following pimozide withdrawal, as well as during subsequent thioridazine administration. It draws the clinician's attention to unusual susceptibility to extrapyraraidal side effects and suggests that if a child shows this type of susceptibility to one neuroleptic, he/she may react similarly to other neuroleptics as well.J. Am. Acad. Child Adolesc. Psychiatry, 1993, 32, 3:640–642.