Demographic and clinical features of critically ill patients with COVID-19 in Greece: The burden of diabetes and obesity
Demographic and clinical features of critically ill patients with COVID-19 in Greece: The burden of diabetes and obesity
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DOI：
10.1016/j.diabres.2020.108331
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发表时间：
2020-08-01
影响因子：
5.1
通讯作者：
Dimopoulos, G.
中科院分区：
文献类型：
--
作者：
Halvatsiotis, P.;Kotanidou, A.;Dimopoulos, G.
目的：该研究的目的是调查2型糖尿病、其他基础疾病和肥胖与希腊重症Covid-19患者结局之间的关系。方法：在这项回顾性观察性多中心研究中，分析了来自希腊8家医院的90例RNA 2109-nCoV确诊重症患者的数据和结局。所有报告的信息截止到2020年4月13日。结果：患者的中位年龄为65.5岁（IQR 56-73），大多数为男性（80%），34.4%的患者最常见于55岁以下。高血压是最常见的合并症（50%），其次是心血管疾病（21.1%）和2型糖尿病（18.9%）。入院时，常见症状持续时间的中位数为8（IQR 5-11）天。13.3%的患者出院，53.4%的患者仍在ICU，28.9%的患者死亡，其住院天数少于存活者[分别为6（IQR 3-9）vs. 9（IQR 7-14.5）]。衰老不是一个危险因素，但糖尿病恶化的结果。结论：2型糖尿病和肥胖可能导致希腊COVID-19重症患者的疾病严重程度和死亡率。(C)2020 Elsevier B. V.保留所有权利。
Aims: The aim of the study was to investigate the association between type-2 diabetes mellitus, other underlying diseases and obesity with the outcomes of critically ill Covid-19 patients in Greece.Methods: In this retrospective observational multi-centre study, data and outcomes of 90 RNA 2109-nCoV confirmed critically ill patients from 8 hospitals throughout Greece, were analysed. All reported information stand through April 13th 2020.Results: The median age of the patients was 65.5 (IQR 56-73), majority were male (80%) and obesity was present in 34.4% of patients most prevalent to younger than 55 years. Hypertension was the prevailing comorbidity (50%), followed by cardiovascular diseases (21.1%) and type-2 diabetes (18.9%). At admission, common symptoms duration had a median of 8 (IQR 5-11) days. A 13.3% of the patients were discharged, 53.4% were still in the ICUs and 28.9% deceased who were hospitalised for fewer days than the survivors [6 (IQR 3-9) vs. 9 (IQR 7-14.5) respectively]. Aging was not a risk factor but diabetes deteriorates the outcomes. Obesity poses a suggestive burden as it was more notable in deceased versus survivors.Conclusions: Type 2 diabetes and obesity may have contributed to disease severity and mortality in COVID-19 critically ill patients in Greece. (C) 2020 Elsevier B.V. All rights reserved.