Universal laws in the force-induced unraveling of biological bonds.
Universal laws in the force-induced unraveling of biological bonds.
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力引起的生物键解体的普遍法则。
DOI：
10.1103/physreve.75.011905
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Prezhdo,OlegV
中科院分区：
文献类型：
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作者：
Pereverzev,YuriyV;Prezhdo,OlegV
根据解离速率常数与作用力的一般函数关系，建立了受体-配体复合体受力诱导解离的普遍定律，并用描述最近发现的生物捕获键的双路径模型进行了详细描述。这些关系将获得的数据与不同区域中的恒定和随时间变化的力联系在一起，为以前不相关的数据集提供了共同的表示，从而极大地促进了对实验的分析和解释。通过P-选择素和P-选择素糖蛋白配体-1之间的单体和二聚体接滑键，以及E-选择素和唾液酸抗原之间的滑动键，证明了这一普遍规律。
Universal laws in the force-induced unbinding of receptor-ligand complexes are established for a general functional dependence of the dissociation rate constant on the applied force and are detailed with the two-pathway model that describes the recently discovered biological catch bond. The relationships link the data obtained with constant and time-dependent forces in different regimes, provide common representation for the previously unrelated data sets, and, thereby, greatly facilitate analysis and interpretation of experiments. The universal laws are demonstrated with the monomeric and dimeric catch-slip bonds between P-selectins and P-selectin glycoprotein ligands-1, and the slip bond between E-selectin and sialylantigen.