Fear of recurrence, treatment satisfaction, and quality of life after radical prostatectomy for prostate cancer
Fear of recurrence, treatment satisfaction, and quality of life after radical prostatectomy for prostate cancer
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DOI：
10.1007/s00520-007-0296-x
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发表时间：
2008-02-01
影响因子：
3.1
通讯作者：
Carroll, Peter R.
中科院分区：
文献类型：
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作者：
Hart, Stacey L.;Latini, David M.;Carroll, Peter R.
前列腺癌患者对癌症复发的恐惧（FOR）很常见，但很少有研究探讨FOR对生活质量（QOL）的影响或这些恐惧加剧的机制。本研究的目的是检查治疗满意度（TS）作为一个主持人之间的关系FOR和QOL.Patients和方法数据来自CaPSURE（TM）数据库，12,000人的国家观察性前列腺癌登记。333例接受根治性前列腺切除术（RP）治疗前列腺癌的患者完成了自我报告。在RP后0-6个月用本研究开发的9项量表测量TS，在RP后6-12个月用先前验证的5项量表测量FOR，在RP后12-18个月用简表36测量QOL。主要结果在控制了年龄、教育、共病疾病数量和癌症严重程度后，（B=-0.12，p < 0.0001）、较高的TS（B=0.09，p < 0.001）以及TS × FOR（B=0.87，p < 0.05）的交互作用显著预测较高的心理健康QOL评分。此外，较低的FOR（B=-0.08，p < 0.01）和TS × FOR的交互作用（B=-1.11，p < 0.01）显著预测较高的身体健康QOL得分。具体而言，与样本中的其他患者相比，报告TS较低和FOR较高的患者支持显著较低的QOL水平。
Goals of work Fear of cancer recurrence (FOR) is common in prostate cancer patients, but little research has examined the impact of FOR on quality of life (QOL) or the mechanism by which these fears become intensified. The objective of this study was to examine treatment satisfaction (TS) as a moderator of the relationship between FOR and QOL.Patients and methods Data were drawn from the CaPSURE (TM) database, a 12,000-man national observational prostate cancer registry. Three hundred and thirty-three patients who underwent radical prostatectomy (RP) to treat their prostate cancer completed self-report measures. TS was measured 0-6 months post-RP with a nine-item scale developed for this study, FOR was measured 6-12 months post-RP with a previously validated five-item scale, and QOL was measured 12-18 months post-RP with the Short Form 36.Main results After controlling for age, education, number of comorbid medical conditions, and cancer severity, lower FOR (B=-0.12, p < 0.0001), higher TS (B=0.09, p < 0.001), and the interaction of TS x FOR (B=0.87, p < 0.05) significantly predicted higher mental health QOL scores. Furthermore, lower FOR (B=-0.08, p < 0.01), and the interaction of TS x FOR (B=-1.11, p < 0.01) significantly predicted higher physical health QOL scores.Conclusions TS levels mitigated the impact of high FOR on lower levels of QOL. Specifically, patients who reported lower TS and greater FOR endorsed significantly lower levels of QOL compared to other patients in the sample.