Schizophrenia and complications of pregnancy and labor:: An individual patient data meta-analysis
Schizophrenia and complications of pregnancy and labor:: An individual patient data meta-analysis
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DOI：
10.1093/oxfordjournals.schbul.a033389
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发表时间：
1999-01-01
影响因子：
6.6
通讯作者：
Murray, RM
中科院分区：
文献类型：
--
作者：
Geddes, JR;Verdoux, H;Murray, RM
几项流行病学研究报告了妊娠和分娩并发症与精神分裂症之间的关联，但没有一项研究具有足够的能力来检查个别低患病率的特定并发症，因此，我们使用使用Lewis-Murray量表的病例对照研究的原始数据进行了个体患者荟萃分析，数据来自700名精神分裂症受试者和835名对照者的12项研究。精神分裂症与胎膜早破、胎龄小于37周、使用复苏或培养箱有显著相关性，与出生体重低于2500 g和产钳分娩有临界相关性。这些并发症与性别之间没有明显的相互作用。我们得出结论，一些妊娠和分娩异常可能与精神分裂症的发展有关。病理生理学可能涉及缺氧，因此未来的研究应侧重于准确测量这种暴露。
Several epidemiological studies have reported an association between complications of pregnancy and delivery and schizophrenia, but none have had sufficient power to examine specific complications that, individually, are of low prevalence, We, therefore, performed an individual patient meta-analysis using the raw data from case control studies that used the Lewis-Murray scale, Data were obtained from 12 studies on 700 schizophrenia subjects and 835 controls. There were significant associations between schizophrenia and premature rupture of membranes, gestational age shorter than 37 weeks, and use of resuscitation or incubator, There were associations of borderline significance between schizophrenia and birthweight lower than 2,500 g and forceps delivery. There was no significant interaction between these complications and sex. We conclude that some abnormalities of pregnancy and delivery may be associated with development of schizophrenia. The pathophysiology may involve hypoxia and so future studies should focus on the accurate measurement of this exposure.