Detection of the SARS-CoV-2 spike protein in saliva with Shrinky-Dink© electrodes.

Detection of the SARS-CoV-2 spike protein in saliva with Shrinky-Dink© electrodes.
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使用 Shrinky-Dink© 电极检测唾液中的 SARS-CoV-2 刺突蛋白。

DOI:
10.1039/d1ay00041a
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发表时间:
2021
期刊:
Analytical methods : advancing methods and applications
影响因子:
--
通讯作者:
Khine,Michelle
Khine,Michelle
中科院分区:
--
文献类型:
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作者:
Zakashansky,JuliaA;Imamura,AmandaH;Salgado2nd,DarwinF;RomeroMercieca,HeatherC;Aguas,RaphaelFL;Lao,AngelouM;Pariser,Joseph;Arroyo-Currás,Netzahualcóyotl;Khine,Michelle

文献摘要

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使用儿童玩具Shrinky-Dink©,我们提出了一种基于适体的电化学(E-AB)测定,其识别唾液中SARS-CoV-2的刺突蛋白用于病毒感染检测。低成本的电极可在群体规模上实现,并证明可检测低至1 ag mL−1的刺突蛋白S1亚基。
Using the children's toy, Shrinky-Dink©, we present an aptamer-based electrochemical (E-AB) assay that recognizes the spike protein of SARS-CoV-2 in saliva for viral infection detection. The low-cost electrodes are implementable at population scale and demonstrate detection down to 1 ag mL−1 of the S1 subunit of the spike protein.