An hsr on chromosome 7 was shown to be an insertion of four copies of the 11q23 MLL gene region in an HIV-related lymphoma
An hsr on chromosome 7 was shown to be an insertion of four copies of the 11q23 MLL gene region in an HIV-related lymphoma
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DOI：
10.1016/s0165-4608(01)00438-1
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发表时间：
2001-09-01
影响因子：
--
通讯作者：
Chan, JA
中科院分区：
文献类型：
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作者：
Reddy, KS;Parsons, L;Chan, JA
一名45岁男性艾滋病提出了盲肠弥漫性大B细胞淋巴瘤。细胞遗传学和荧光原位杂交（FISH）研究揭示了一个复杂的核型与多种畸变，包括易位，t（8;14）涉及MYC的14号染色体上。这是B细胞淋巴瘤特有的。还经常观察到继发性变化，如染色体I重排导致Iq三体和缺失的17号染色体的tp 53缺失。一个独特的继发性异常是7号染色体上的hsr，通过FISH和SKY研究表明，它起源于11号染色体，涉及4个拷贝的MLL基因区域。(C)2001 Elsevier Science Inc.保留所有权利。
A 45-year-old male with AIDS presented with a cecal diffuse large B-cell lymphoma. Cytogenetic and flourescence in situ hybridization (FISH) studies revealed a complex karyotype with multiple aberrations that included a translocation, t(8;14) involving MYC on chromosome 14. This is specific to B-cell lymphomas. There were also frequently observed secondary changes such as chromosome I rearrangement leading to trisomy of Iq and loss of tp53 from the deleted chromosome 17. A unique secondary abnormality was an hsr on chromosome 7, which by FISH and SKY investigations was shown to originate from chromosome 11 involving 4 copies of the MLL gene region. (C) 2001 Elsevier Science Inc. All rights reseserved.