Studies of the development of congenital anomalies in embryos of riboflavin-deficient, galactoflavin fed rats. II. Role of the terminal elec-tron transport systems.
Studies of the development of congenital anomalies in embryos of riboflavin-deficient, galactoflavin fed rats. II. Role of the terminal elec-tron transport systems.
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对核黄素缺乏、半乳黄素喂养的大鼠胚胎先天性异常发育的研究。
DOI：
10.1002/tera.1420010110
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发表时间：
1968
期刊：
影响因子：
--
通讯作者：
R. Lemire
中科院分区：
文献类型：
--
作者：
O. Aksu;B. Mackler;T. Shepard;R. Lemire
用缺乏核黄素、添加半乳黄素的饲料处理孕期大鼠胚胎和胎儿组织的研究表明，在发育的关键时期(妊娠12天至16天)，琥珀酸氧化酶和DPNH氧化酶系统(末端电子传递系统)的活性明显低于对照组。在同一时期，胎盘组织和母体心脏组织的电子传递系统的活动没有受到影响，这表明胎儿组织特别容易受到核黄素缺乏的影响。
Studies of the tissues of embryos and fetuses of rats treated with a riboflavin-deficient, galactoflavin-augmented diet during pregnancy were performed, and demonstrated that the activities of the succinic and DPNH oxidase systems (the terminal electron transport systems) were markedly reduced from control values during the critical period of development (days 12 thru 16 of gestation). The activities of the electron transport systems of placental tissue and maternal heart tissue were unaffected during the same period, suggesting that fetal tissue is particularly susceptible to the effects of riboflavin deficiency.