Quantitative diffusion tensor MRI-based fiber tracking of human skeletal muscle
Quantitative diffusion tensor MRI-based fiber tracking of human skeletal muscle
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DOI：
10.1152/japplphysiol.00290.2007
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发表时间：
2007-08-01
影响因子：
3.3
通讯作者：
Damon, Bruce M.
中科院分区：
文献类型：
--
作者：
Lansdown, Drew A.;Ding, Zhaohua;Damon, Bruce M.
弥散张量磁共振成像(DT-MRI)为了解人体骨骼肌的结构-功能关系提供了巨大的潜力。本研究的目的是证明利用在体人DT-MRI纤维追踪数据进行羽状角测量的可行性，并验证胫骨前肌腱膜方向的异质性会导致羽状角的异质性的假说。对8名健康受试者(5名男性)进行研究。获取TA肌的T1加权解剖MRI和DT-MRI数据。通过主特征向量追踪TA的腱膜纤维。确定了腱膜束和肌纤维束在实验室参照系中的方位，以及纤维束相对于腱膜的方位[即羽状角(Theta)]。当相对于实验室参照系表达时，肌肉纤维的取向不会作为优劣位置的函数改变。腱膜的矢状位和冠状位也无明显改变，但其轴向的改变与40°相近。结果，沿着肌肉从上到下的方向，theta的平均值从16.3度(SD 6.9)下降到11.4度(SD 5.0)。脑室深部的平均电位值大于浅层脑室。我们得出结论，利用DT-MRI肌肉纤维跟踪技术测量人体肌肉的羽状角是可行的，并揭示了在足头方向上，人类TA肌肉的羽状特征存在异质性。
Diffusion-tensor magnetic resonance imaging (DT-MRI) offers great potential for understanding structure-function relationships in human skeletal muscles. The purposes of this study were to demonstrate the feasibility of using in vivo human DT-MRI fiber tracking data for making pennation angle measurements and to test the hypothesis that heterogeneity in the orientation of the tibialis anterior ( TA) muscle's aponeurosis would lead to heterogeneity in pennation angle. Eight healthy subjects ( 5 male) were studied. T-1-weighted anatomical MRI and DT-MRI data were acquired of the TA muscle. Fibers were tracked from the TA's aponeurosis by following the principal eigen-vector. The orientations of the aponeurosis and muscle fiber tracts in the laboratory frame of reference and the orientation of the fiber tracts with respect to the aponeurosis [i. e., the pennation angle (theta)] were determined. The muscle fiber orientations, when expressed relative to the laboratory frame of reference, did not change as functions of superior-to-inferior position. The sagittal and coronal orientations of the aponeurosis did not change in practically significant manners either, but the aponeurosis' axial orientation changed by similar to 40 degrees. As a result, the mean value for theta decreased from 16.3 (SD 6.9) to 11.4 degrees ( SD 5.0) along the muscle's superior-to-inferior direction. The mean value of theta was greater in the deep than in the superficial compartment. We conclude that pennation angle measurements of human muscle made using DT-MRI muscle fiber tracking are feasible and reveal that in the foot-head direction, there is heterogeneity in the pennation properties of the human TA muscle.