Estrogens and progestins enhance spatial learning of intact and ovariectomized rats in the object placement task
Estrogens and progestins enhance spatial learning of intact and ovariectomized rats in the object placement task
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DOI：
10.1016/j.nlm.2007.04.003
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发表时间：
2007-09-01
影响因子：
2.7
通讯作者：
Walf, Alicia A.
中科院分区：
文献类型：
--
作者：
Frye, Cheryl A.;Duffy, Caryn K.;Walf, Alicia A.
类固醇对认知功能的调节主要集中在雌激素（E,），但黄体酮自然地与E共变，也可能影响认知表现。研究对象放置任务中的空间表现，包括内源性激素状态E和孕激素的变化，以及服用E-2和/或孕激素的情况。实验1：发情期大鼠和发情期大鼠在物体放置任务中的表现明显优于发情期大鼠。实验2：孕晚期、产后和哺乳期大鼠在物体放置任务中的表现明显优于孕早期大鼠。实验3：去卵巢（ovx）大鼠在物体放置任务训练后立即给予17 β -雌二醇（0.9 mg/kg）、皮下注射（sc）、孕酮（P; 4 mg/kg, sc）或E-2和P，在4小时后的测试中表现明显优于对照组大鼠给药（0.2 cc香油）。实验4：在物体放置任务训练后延迟1.5 h给予E-2或P的ovx大鼠的表现与给予车辆的对照组没有差异。实验5：训练后给药的大鼠在物体放置任务中的表现明显优于给药的大鼠，前者对E-2受体(ER) α和β亚型都有高亲和力，而后者对ER α的选择性比ER β高，PPT, 0.9 mg/kg, sc)。实验6：训练后立即给予P或其代谢物5 α -孕-3 α -醇-20- 1 （3 α,5 α - thp; 4 mg/kg, sc）的ovx大鼠在物体放置任务中的表现明显优于对照大鼠。因此，当E-2和/或P自然升高或E-2， ER α选择性ER调节剂PPT， P或其代谢物3a，5a-THP在训练后给予时，在物体放置任务中的表现更好。(C) 2007爱思唯尔公司版权所有。
Steroid modulation of cognitive function has focused on estrogen (E,), but progestins naturally co-vary with E, and may also influence cognitive performance. Spatial performance in the object placement task over endogenous hormonal states in which E, and progestins vary, and when E-2 and/or progestins were administered, was examined. Experiment 1: Rats in proestrus or estrus had significantly better performance in the object placement task than did diestrus rats. Experiment 2: Rats in the third trimester, post-partum, or lactation exhibited significantly better performance in the object placement task than did rats in the first trimester. Experiment 3: Ovariectomized (ovx) rats administered 17 beta-estradiol (0.9 mg/kg), subcutaneously (sc), progesterone (P; 4 mg/kg, sc), or E-2 and P, immediately after training in the object placement task, performed significantly better when tested 4 h later, than did control rats administered vehicle (sesame oil 0.2 cc). Experiment 4: ovx rats administered E-2 or P with a 1.5 h delay after training in the object placement task, did not perform differently than vehicle-administered controls. Experiment 5: ovx rats administered post-training E,, which has a high affinity for both E-2 receptor (ER)alpha and beta isoforms, or propyl pyrazole triol (PPT; 0.9 mg/kg, sc), which is more selective for ER alpha than ER beta, had significantly better performance in the object placement task than did rats administered vehicle or diarylpropionitrile (DPN; 0.9 mg/kg, sc), an ER beta selective ligand. Experiment 6: ovx rats administered P, or its metabolite, 5 alpha-pregnan-3 alpha-ol-20-one (3 alpha,5 alpha-THP; 4 mg/kg, sc), immediately post-training performed significantly better in the object placement task than did vehicle control rats. Thus, performance in the object placement task is better when E-2 and/or P are naturally elevated or when E-2, the ER alpha selective ER modulator PPT, P, or its metabolite, 3a,5a-THP, are administered post-training. (C) 2007 Elsevier Inc. All rights reserved.