INTERACTIONS BETWEEN BODY-TEMPERATURE AND WHEEL RUNNING OVER THE ESTROUS-CYCLE IN RATS
INTERACTIONS BETWEEN BODY-TEMPERATURE AND WHEEL RUNNING OVER THE ESTROUS-CYCLE IN RATS
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DOI：
10.1016/0031-9384(91)90334-k
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发表时间：
1991-06-01
影响因子：
2.9
通讯作者：
SATINOFF, E
中科院分区：
文献类型：
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作者：
KENT, S;HURD, M;SATINOFF, E
将雌性大鼠饲养在Wahmann轮中，在12：12光暗（LD）光周期下饲养36天，然后转换为LD 10：14，饲养36-64天。 跑步是95-100%的夜间活动。 LD 12：12的跑步总量较高，但动情周期的变化相似。 与间情期第一夜相比，在发情前期的夜晚，LD 12：12和LD 10：14的奔跑增加了64%和123%（p < 0.0001）。 夜间结核病与跑步水平相关。 在LD 12：12中，动情前期的Tb比动情间期-1高0.3 +/- 0.0 ℃（p < 0.0001）;在LD 10：14中，Tb比动情间期-1高0.2 +/- 0.0 ℃（p < 0.001）。 L期，Tb在发情前期最低，发情期最高。 一半的大鼠表现出一致的相位提前至少30分钟的Tb和活动的发情前期。 晚期Tb顶相与活动顶相（r = 0.91; p < 0.0001）和跑步量（r = 0.60; p < 0.01）相关。 然后在LD 10：14的晚上将6只大鼠的轮子锁定。 在整个周期中，与间情期-1相比，Tb没有显著变化。 然而，在这些大鼠中，Tb顶相平均延迟76 +/-16分钟（p < 0.01）。 此外，在发情周期的所有天数中，与轮子打开时相比，Tb顶相延迟了94 +/- 18分钟（p < 0.001）。 在LD 12：12和10：14下饲养在盆笼中的6只大鼠显示出与锁定轮中的大鼠相似的Tb变化，并且发情前期的Tb顶相甚至更延迟（平均128 +/- 20 min）。 这些数据表明，大部分的Tb的变化在发情周期的活动变化有关，激素对Tb的影响是轻微的。
Female rats were housed in Wahmann wheels under a 12:12 light-dark (LD) photoperiod for 36 days and then were switched to LD 10:14 for 36-64 days. Running was 95-100% nocturnal. Overall amounts of running were higher in LD 12:12, but changes over the estrous cycle were similar. On the night of proestrus running increased by 64% in LD 12:12 and 123% in LD 10:14 (p < 0.0001) compared to the first night of diestrus. Nighttime Tb's were correlated with running levels. In LD 12:12 Tb on proestrus was higher by 0.3 +/- 0.0-degrees-C (p < 0.0001); in LD 10:14 it was higher by 0.2 +/- 0.0-degrees-C (p < 0.001) compared to diestrus-1. During L, Tb was lowest on proestrus and highest on estrus. Half of the rats exhibited a consistent phase advance of at least 30 min in both Tb and activity on proestrus. The advanced Tb acrophase was correlated with both the activity acrophase (r = .91; p < 0.0001) and the amount of running (r = .60; p < 0.01). The wheels of 6 rats were then locked at night in LD 10:14. There were no significant Tb changes from diestrus-1 across the cycle. However, Tb acrophase was delayed a mean of 76 +/- 16 min (p < 0.01) in these rats. Also, the Tb acrophase across all days of the estrous cycle was delayed by 94 +/- 18 min (p < 0.001) compared to when the wheels were open. Six rats that were housed in basin cages under LD 12:12 and then 10:14 showed changes in Tb that were similar to the rats in the locked wheels, and Tb acrophases on proestrus were even more delayed (mean 128 +/- 20 min). These data suggest that most of the Tb changes over the estrous cycle are related to changes in activity, and that the hormonal influence on Tb is minor.