Human Antibody Response to Anopheles gambiae Saliva: An Immuno-Epidemiological Biomarker to Evaluate the Efficacy of Insecticide-Treated Nets in Malaria Vector Control
Human Antibody Response to Anopheles gambiae Saliva: An Immuno-Epidemiological Biomarker to Evaluate the Efficacy of Insecticide-Treated Nets in Malaria Vector Control
复制标题
DOI：
10.4269/ajtmh.2010.09-0684
复制
发表时间：
2010-07-01
影响因子：
3.3
通讯作者：
Remoue, Franck
中科院分区：
文献类型：
--
作者：
Drame, Papa M.;Poinsignon, Anne;Remoue, Franck
为了抗击疟疾，世界卫生组织（WHO）强调需要制定指标来评估病媒控制策略的有效性。这项研究基于人类对按蚊唾液的抗体反应，研究了一种潜在的免疫学标记，作为评估杀虫剂处理蚊帐 (ITN) 功效的新指标。在引入驱虫蚊帐之前和之后，对安哥拉疟疾流行地区的儿童和成人进行了寄生虫学、昆虫学和免疫学评估。免疫球蛋白 G (IgG) 水平达到 An。冈比亚唾液与按蚊强度呈正相关。冈比亚暴露和疟疾感染。引入 ITN 后观察到抗唾液 IgG 反应显着下降，这与寄生虫负载的下降有关。这项研究代表了评估疟疾病媒控制策略有效性的新指标开发的第一阶段，该指标可应用于其他节肢动物媒介传播的疾病。
For the fight against malaria, the World Health Organization (WHO) has emphasized the need for indicators to evaluate the efficacy of vector-control strategies. This study investigates a potential immunological marker, based on human antibody responses to Anopheles saliva, as a new indicator to evaluate the efficacy of insecticide-treated nets (ITNs). Parasitological, entomological, and immunological assessments were carried out in children and adults from a malaria-endemic region of Angola before and after the introduction of ITNs. Immunoglobulin G (IgG) levels to An. gambiae saliva were positively associated with the intensity of An. gambiae exposure and malaria infection. A significant decrease in the anti-saliva IgG response was observed after the introduction of ITNs, and this was associated with a drop in parasite load. This study represents the first stage in the development of a new indicator to evaluate the efficacy of malaria vector-control strategies, which could apply in other arthropod vector-borne diseases.