Mapping human development at single-cell resolution
Mapping human development at single-cell resolution
复制标题
DOI：
10.1242/dev.152561
复制
发表时间：
2018-02-01
期刊：
影响因子：
4.6
通讯作者：
Haniffa, Muzlifah
中科院分区：
文献类型：
--
作者：
Behjati, Sam;Lindsay, Susan;Haniffa, Muzlifah
人类发育受到时空限制的分子程序的调控，与基础生物学和人类医学的许多领域有关，如干细胞生物学、生殖医学和儿童癌症。绘制人类发展地图提出了重大的技术、后勤和伦理挑战。已建立的人类发育生物库的出现和尖端单细胞技术的出现为研究人类发展提供了新的机会。在这里，我们提出了一个利用单细胞基因组学和空间分析建立人类发育细胞图谱的工作框架。我们讨论了开发图集将如何使科学和临床社区受益，以促进我们对基础生物学、健康和疾病的理解。
Human development is regulated by spatiotemporally restricted molecular programmes and is pertinent to many areas of basic biology and human medicine, such as stem cell biology, reproductive medicine and childhood cancer. Mapping human development has presented significant technological, logistical and ethical challenges. The availability of established human developmental biorepositories and the advent of cutting-edge single-cell technologies provide new opportunities to study human development. Here, we present a working framework for the establishment of a human developmental cell atlas exploiting single-cell genomics and spatial analysis. We discuss how the development atlas will benefit the scientific and clinical communities to advance our understanding of basic biology, health and disease.