Transcriptional and epigenetic regulation of innate-like T lymphocyte development.
Transcriptional and epigenetic regulation of innate-like T lymphocyte development.
复制标题
先天样 T 淋巴细胞发育的转录和表观遗传调控。
DOI：
10.1016/j.coi.2018.01.006
复制
发表时间：
2018
影响因子：
7
通讯作者：
Kee,BarbaraL
中科院分区：
文献类型：
--
作者：
Verykokakis,Mihalis;Kee,BarbaraL
亮点iNKT细胞的一个小亚群来自于糖尿病肾病细胞，绕过了DP阶段。iNKT TCR的构象变化调节iNKT细胞的命运。脂肪组织驻留的NKT10细胞来自胸腺。iNKT细胞亚群之间的整体转录和表观遗传学特征不同。表观遗传调节因子控制着靠近谱系特异基因的染色质的可及性。不变的自然杀伤T细胞(INKT)是识别脂类抗原的异质性天然T细胞群体。尽管其T细胞受体具有单特异性，但iNKT细胞在胸腺发育过程中，在遇到外来抗原之前，会分化成稳定的亚系。INKT细胞亚群如何获得和维持其功能程序是先天淋巴细胞生物学的中心问题。INKT亚集的全球转录和表观遗传学特征提供了对这些亚集的内部连接的洞察，这些亚集定义了它们的身份。将iNKT转录程序与其他适应性和先天淋巴细胞谱系的转录程序进行比较，发现了可能决定效应器功能的共同核心调控电路。本文就iNKT细胞发育的分子机制研究进展作一综述。
HighlightsA minor subset of iNKT cells derives from DN cells, bypassing the DP stage.Conformational changes in iNKT TCR regulate iNKT cell fate.Adipose tissue resident NKT10 cells originate from the thymus.Global transcriptional and epigenetic profiles vary among iNKT cell subsets.Epigenetic regulators control chromatin accessibility near lineage-specific genes.Invariant Natural Killer T (iNKT) cells are a heterogeneous innate T cell population that recognizes lipid antigens. Despite the monospecific nature of their T cell receptor, iNKT cells differentiate into stable sublineages during thymic development, before foreign antigen encounter. How iNKT cell subsets acquire and maintain their functional programs is a central question in innate lymphocyte biology. Global transcriptional and epigenetic profiling of iNKT subsets has provided insights into the internal wiring of these subsets that defines their identity. Comparison of the iNKT transcriptional programs with those of other adaptive and innate lymphocyte lineages revealed common core regulatory circuits that may dictate effector functions. In this review, we summarize recent advances on the molecular mechanisms involved in iNKT cell development.