The nature and effects of cortical microvascular pathology in aging and Alzheimer's disease
The nature and effects of cortical microvascular pathology in aging and Alzheimer's disease
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DOI：
10.1179/016164104225016272
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发表时间：
2004-07-01
影响因子：
1.9
通讯作者：
Hof, PR
中科院分区：
文献类型：
--
作者：
Bailey, TL;Rivara, CB;Hof, PR
年龄相关和淀粉样蛋白诱导的大脑微血管病理已被认为是阿尔茨海默病（AD）发病的潜在因素。微血管系统在维持大脑稳态中起着至关重要的作用，其完整性的恶化可能对AD患者的脑功能产生有害影响，可能导致神经原纤维变性、斑块形成和细胞损失。脑血管在血液和大脑之间的各种物质交换过程中起着重要的作用，具有特殊的解剖和生理特性，对维持神经元环境的离子稳态具有高度的调节作用。在这里，我们回顾了皮层微血管在衰老和AD中的神经病理学方面与已知心血管危险因素的关系，以及它们对晚发性痴呆中认知能力下降的可能影响。
Age-related and amyloid-induced pathology of the cerebral microvasculature have been implicated as potential contributing factors to the pathogenesis of Alzheimer's disease (AD). The microvasculature plays a crucial role in maintaining brain homeostasis and deterioration of its integrity may have deleterious effects on brain function in AD, possibly leading to neurofibrillary degeneration, plaque formation, and cell loss. Brain vessels possess peculiar anatomical and physiological properties owing to their role in the exchange processes of various substances between blood and brain, which are highly regulated for the maintenance of ionic homeostasis of the neuronal environment. Here we review neuropathological aspects of cortical microvessels in aging and AD in relationship to known cardiovascular risk factors and their possible impact on the cognitive decline seen in late-onset dementia.