A model for the coupling between cerebral blood flow and oxygen metabolism during neural stimulation
A model for the coupling between cerebral blood flow and oxygen metabolism during neural stimulation
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DOI：
10.1097/00004647-199701000-00009
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发表时间：
1997-01-01
影响因子：
6.3
通讯作者：
Frank, LR
中科院分区：
文献类型：
--
作者：
Buxton, RB;Frank, LR
基于假设所有脑毛细血管在静止时都灌注，并且从毛细血管中提取的所有氧均已代谢，则提出了将O-2传递给大脑的一般数学模型。该模型预测，为了支持O-2代谢率的微小变化，需要进行血流的较大变化。根据该模型的解释，在神经刺激过程中对人脑的先前正电子发射断层扫描（PET）研究表明，脑血流（CBF）的增加远大于氧代谢率，与流量的紧密偶联和氧化代谢的紧密耦合一致。该模型为局部CBF的变化而言，对功能磁共振成像（fMRI）研究的定量解释提供了基础。
A general mathematical model for the delivery of O-2 to the brain is presented, based on the assumptions that all of the brain capillaries are perfused at rest and that all of the oxygen extracted from the capillaries is metabolized. The model predicts that disproportionately large changes in blood flow are required in order to support small changes in the O-2 metabolic rate. Interpreted in terms of this model, previous positron emission tomography (PET) studies of the human brain during neural stimulation demonstrating that cerebral blood flow (CBF) increases much more than the oxygen metabolic rate are consistent with tight coupling of flow and oxidative metabolism. The model provides a basis for the quantitative interpretation of functional magnetic resonance imaging (fMRI) studies in terms of changes in local CBF.