Articulatory Gain Predicts Motor Cortex and Subthalamic Nucleus Activity During Speech
Articulatory Gain Predicts Motor Cortex and Subthalamic Nucleus Activity During Speech
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DOI：
10.1093/cercor/bhab251
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发表时间：
2021-09-01
期刊：
影响因子：
3.7
通讯作者：
Richardson, R. M.
中科院分区：
文献类型：
--
作者：
Dastolfo-Hromack, C.;Bush, A.;Richardson, R. M.
准确地说话对于有效的语言交流很重要，而发音增益是有助于实现这一目标的言语运动控制的一个组成部分。鉴于基底神经节已被提出来调节肢体运动的速度和大小，即运动增益，我们探讨了基底神经节的贡献，通过局部场电位（LFP）记录同时从丘脑底核（ESTA），中央前回，中央后回。在帕金森病的脑深部电刺激植入过程中，参与者大声朗读辅音-元音-辅音音节。发音增益使用F2比率间接评估，F2比率是/i/元音除以/u/元音的第二共振峰频率的声学测量。混合效应模型表明，F2比率与中央前回和海马的α和θ活动相关。中央后回没有观察到相关性。功能连接分析显示，较高的锁相值之间的β活动的海马回和中央前回与较低的F2比率，表明较高的β同步损害发音精度。影响与疾病严重程度无关。这些数据表明，发音增益编码内的基底神经节皮质回路。
Speaking precisely is important for effective verbal communication, and articulatory gain is one component of speech motor control that contributes to achieving this goal. Given that the basal ganglia have been proposed to regulate the speed and size of limb movement, that is, movement gain, we explored the basal ganglia contribution to articulatory gain, through local field potentials (LFP) recorded simultaneously from the subthalamic nucleus (STN), precentral gyrus, and postcentral gyrus. During STN deep brain stimulation implantation for Parkinson's disease, participants read aloud consonant-vowel-consonant syllables. Articulatory gain was indirectly assessed using the F2 Ratio, an acoustic measurement of the second formant frequency of/i/vowels divided by/u/vowels. Mixed effects models demonstrated that the F2 Ratio correlated with alpha and theta activity in the precentral gyrus and STN. No correlations were observed for the postcentral gyrus. Functional connectivity analysis revealed that higher phase locking values for beta activity between the STN and precentral gyrus were correlated with lower F2 Ratios, suggesting that higher beta synchrony impairs articulatory precision. Effects were not related to disease severity. These data suggest that articulatory gain is encoded within the basal ganglia-cortical loop.