Hepatitis B Virus Infection Rate and Distribution in Chinese Systemic Lupus Erythematosus Patients.
Hepatitis B Virus Infection Rate and Distribution in Chinese Systemic Lupus Erythematosus Patients.
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中国系统性红斑狼疮患者乙型肝炎病毒感染率及分布
DOI：
10.12659/msm.893691
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发表时间：
2015-07-06
期刊：
影响因子：
--
通讯作者：
Yu X
中科院分区：
文献类型：
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作者：
Chen X;Hong L;Zhang W;Yuan M;Yang Q;Mao H;Chen W;Yu X
本研究的目的是调查中国系统性红斑狼疮（SLE）患者的B型肝炎病毒（HBV）感染率，并确定其年龄和性别分布。方法回顾性调查1996年1月至2011年12月中山大学附属第一医院确诊的3981例SLE患者的HBV感染率。将2000年全国人口普查数据标准化，并与2006年全国普查结果进行比较。中国SLE患者的年龄和性别标化HBV感染率为3.3%。年龄、性别标化抗HBcAb阳性率分别为58.1%和26.1%。与2006年全国流行病学调查结果相比，15-49岁SLE患者HBV感染率和HBcAb阳性率均低于普通人群，而HBcAb阳性率高于普通人群。SLE患者中HBV感染率在男性和女性之间无差异（4.2% vs.2.8%，p=0.088）。SLE患者HBV感染率较普通人群低，但儿童和50岁以上患者HBV感染率无明显差异。与一般人群不同，SLE患者中HBV感染率在男性和女性之间无统计学差异。
The aim of this study was to investigate the hepatitis B virus (HBV) infection rate in systemic lupus erythematosus (SLE) patients in China, and to determine the age and sex distribution. A total of 3981 SLE patients diagnosed in The First Affiliated Hospital of Sun Yat-sen University from January 1996 to December 2011 were retrospectively investigated for evaluation of the HBV infection rate. The HBV infection rate and the positive rate of hepatitis B surface antibody (HBsAb) and hepatitis B core antibody (HBcAb) were standardized to national census data in 2000 and compared with the prevalence found in the 2006 national survey. The age and sex standardized HBV infection rate in Chinese SLE patients was 3.3%. The age and sex standardized positive rate of HBsAb and HBcAb were 58.1% and 26.1%, respectively. As compared with the prevalence from the 2006 national survey, the HBV infection rate and the positive rate of HBcAb were lower and the positive rate of HBsAb was higher in SLE patients aged 15–49 years old compared to peers in the general population. There was no difference in HBV infection rate between males and females (4.2% vs. 2.8%, p=0.088) in SLE patients. The HBV infection rate was relatively lower in SLE patients compared with the general population, but there was no difference in pediatric patients or patients aged above 50 years old. Unlike in the general population, the HBV infection rate had no statistical differences between males and females in SLE patients.