Occurrence of premature chromosome condensation in mouse spermatogonia treated with busulfan.
Occurrence of premature chromosome condensation in mouse spermatogonia treated with busulfan.
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用白消安处理的小鼠精原细胞中发生过早染色体浓缩。
DOI：
10.1159/000132310
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Y. Kikuchi
中科院分区：
文献类型：
--
作者：
K. Yamamoto;S. Hitotsumachi;Y. Kikuchi
在小鼠精原细胞中检查了白消安对染色体过早浓缩（PCC）的诱导作用。成年（C3H X SWV）F1雄性小鼠按10或30 mg/kg体重腹腔注射白消安，并在18-72小时后处死。在未治疗组和治疗组中，多倍体样有丝分裂很常见（约占所有检查的精原细胞有丝分裂的 1/4）。其中大部分被认为源自正常精原细胞。在白消安治疗的小鼠中，观察到具有 PCC 的多倍体样有丝分裂。含有PCC的有丝分裂的频率随着剂量和暴露时间的增加而增加。讨论了小鼠精原细胞中 PCC 诱导的可能解释。
Busulfan induction of premature chromosome condensation (PCC) was examined in mouse spermatogonia. Adult (C3H X SWV) F1 male mice were injected intraperitoneally with busulfan at 10 or 30 mg/kg of body weight and killed 18-72 h later. Polyploid-like mitoses were frequent (ca. 1/4 of all spermatogonial mitoses examined) in both the untreated and treated groups. Most of these were considered to have been derived from normal spermatogonia. In busulfan-treated mice, polyploid-like mitoses with PCC were seen. The frequency of PCC-containing mitoses increased with increasing dose and exposure time. A possible interpretation for PCC induction in mouse spermatogonia is discussed.