Cortical thickness in obsessive compulsive disorder: multisite mega-analysis of 780 brain scans from six centres
Cortical thickness in obsessive compulsive disorder: multisite mega-analysis of 780 brain scans from six centres
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DOI：
10.1192/bjp.bp.115.164020
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发表时间：
2017-01-01
影响因子：
10.5
通讯作者：
van den Heuvel, Odile A.
中科院分区：
文献类型：
--
作者：
Fouche, Jean-Paul;du Plessis, Stefan;van den Heuvel, Odile A.
目的研究强迫症患者皮质厚度和皮质下体积的变化。方法对412例强迫症患者和368例健康成人进行磁共振成像检查。结果强迫症组额上回、下回、中央前回、扣带后回、颞中回、顶下回、楔前回皮质厚度明显低于对照组。强迫症组的顶叶皮质也存在年龄交互作用，随着年龄的增长，顶叶皮质厚度变薄。结论我们的发现与早期的工作部分一致，提示灰质体积和皮质厚度的组间差异可能与强迫症相同的潜在病理机制有关。他们部分支持强迫症的额纹状体模型，但也表明边缘、颞区和顶区在强迫症的病理生理学中发挥了作用。年龄的交互作用可能是神经可塑性改变的结果。版权和用法(C)，2017年皇家精神病学家学院。
BackgroundThere is accumulating evidence for the role of fronto-striatal and associated circuits in obsessive -compulsive disorder (OCD) but limited and conflicting data on alterations in cortical thickness.AimsTo investigate alterations in cortical thickness and subcortical volume in OCD.MethodIn total, 412 patients with OCD and 368 healthy adults underwent magnetic resonance imaging scans. Between group analysis of covariance of cortical thickness and subcortical volumes was performed and regression analyses undertaken.ResultsSignificantly decreased cortical thickness was found in the OCD group compared with controls in the superior and inferior frontal, precentral, posterior cingulate, middle temporal, inferior parietal and precuneus gyri. There was also a group x age interaction in the parietal cortex, with increased thinning with age in the OCD group relative to controls.ConclusionsOur findings are partially consistent with earlier work, suggesting that group differences in grey matter volume and cortical thickness could relate to the same underlying pathology of OCD. They partially support a frontostriatal model of OCD, but also suggest that limbic, temporal and parietal regions play a role in the pathophysiology of the disorder. The group x age interaction effects may be the result of altered neuroplasticity.Copyright and usage(C) The Royal College of Psychiatrists 2017.