Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease
Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease
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DOI：
10.1016/j.neulet.2009.02.016
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发表时间：
2009-04-03
影响因子：
2.5
通讯作者：
Ohno, Kinji
中科院分区：
文献类型：
--
作者：
Fu, Yuan;Ito, Mikako;Ohno, Kinji
分子氢作为一种抗氧化剂，减少羟基自由基，但不是其他活性氧和氮物种。在过去的一年中，分子氢已被报道可以预防或改善啮齿动物的八种疾病和人类的一种与氧化应激相关的疾病。在帕金森病中，线粒体功能障碍和相关的氧化应激是黑质多巴胺能细胞损失的主要原因。我们研究了在帕金森病大鼠模型中，在立体定向手术之前或之后，饮用水中类似于50%饱和分子氢对6-羟基多巴胺诱导的黑质变性的影响。甲基苯丙胺诱导的行为分析表明，分子氢阻止了黑质退化的发展和进展。黑质和纹状体的酪氨酸羟化酶染色也表明，用氢预处理和后处理防止多巴胺能细胞损失。我们的研究表明，氢水可能能够延缓帕金森病的发展和进展。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
Molecular hydrogen serves as an antioxidant that reduces hydroxyl radicals, but not the other reactive oxygen and nitrogen species. In the past year, molecular hydrogen has been reported to prevent or ameliorate eight diseases in rodents and one in human associated with oxidative stress. In Parkinson's disease, mitochondrial dysfunction and the associated oxidative stress are major causes of dopaminergic cell loss in the substantia nigra. We examined effects of similar to 50%-saturated molecular hydrogen in drinking water before or after the stereotactic surgery on 6-hydroxydopamine-induced nigrostrital degeneration in a rat model of Parkinson's disease. Methamphetamine-induced behavioral analysis showed that molecular hydrogen prevented both the development and progression of the nigrostrital degeneration. Tyrosine hydroxylase staining of the substantia nigra and striatum also demonstrated that pre- and post-treatment with hydrogen prevented the dopaminergic cell loss. Our studies suggest that hydrogen water is likely able to retard the development and progression of Parkinson's disease. (C) 2009 Elsevier Ireland Ltd. All rights reserved.